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Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review

This systematic review aims to offer an updated understanding of the relationship between omega-3 supplementation and/or vitamin D and autism spectrum disorders (ASD). The databases PubMed, Cochrane Library, Web of Science, EMBASE, CINAHL, Vip, CNKI, Wanfang, China Biomedical Database databases were...

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Autores principales: Jiang, Yuwei, Dang, Wenjun, Nie, Hong, Kong, Xiangying, Jiang, Zhimei, Guo, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466790/
https://www.ncbi.nlm.nih.gov/pubmed/37654990
http://dx.doi.org/10.3389/fpsyt.2023.1238973
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author Jiang, Yuwei
Dang, Wenjun
Nie, Hong
Kong, Xiangying
Jiang, Zhimei
Guo, Jin
author_facet Jiang, Yuwei
Dang, Wenjun
Nie, Hong
Kong, Xiangying
Jiang, Zhimei
Guo, Jin
author_sort Jiang, Yuwei
collection PubMed
description This systematic review aims to offer an updated understanding of the relationship between omega-3 supplementation and/or vitamin D and autism spectrum disorders (ASD). The databases PubMed, Cochrane Library, Web of Science, EMBASE, CINAHL, Vip, CNKI, Wanfang, China Biomedical Database databases were searched using keywords, and relevant literature was hand-searched. Papers (n = 1,151) were systematically screened and deemed eligible since 2002. Twenty clinical controlled studies were included in the final review. The findings were analyzed for intervention effects focusing on the core symptoms of ASD, included social functioning, behavioral functioning, speech function and biomarkers changes. The review found that the effects of omega-3 supplementation on ASD were too weak to conclude that core symptoms were alleviated. Vitamin D supplementation improved core symptoms, particularly behavioral functioning, however, the results of the literatures included in this study were slightly mixed, we cannot directly conclude that vitamin D supplementation has a beneficial effect on a specific symptom of ASD, but the overall conclusion is that vitamin D supplementation has a positive effect on behavioral functioning in ASD. Omega-3 and vitamin D combination supplementation has a good combined effect on social and behavioral outcomes in patients with ASD.
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spelling pubmed-104667902023-08-31 Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review Jiang, Yuwei Dang, Wenjun Nie, Hong Kong, Xiangying Jiang, Zhimei Guo, Jin Front Psychiatry Psychiatry This systematic review aims to offer an updated understanding of the relationship between omega-3 supplementation and/or vitamin D and autism spectrum disorders (ASD). The databases PubMed, Cochrane Library, Web of Science, EMBASE, CINAHL, Vip, CNKI, Wanfang, China Biomedical Database databases were searched using keywords, and relevant literature was hand-searched. Papers (n = 1,151) were systematically screened and deemed eligible since 2002. Twenty clinical controlled studies were included in the final review. The findings were analyzed for intervention effects focusing on the core symptoms of ASD, included social functioning, behavioral functioning, speech function and biomarkers changes. The review found that the effects of omega-3 supplementation on ASD were too weak to conclude that core symptoms were alleviated. Vitamin D supplementation improved core symptoms, particularly behavioral functioning, however, the results of the literatures included in this study were slightly mixed, we cannot directly conclude that vitamin D supplementation has a beneficial effect on a specific symptom of ASD, but the overall conclusion is that vitamin D supplementation has a positive effect on behavioral functioning in ASD. Omega-3 and vitamin D combination supplementation has a good combined effect on social and behavioral outcomes in patients with ASD. Frontiers Media S.A. 2023-08-16 /pmc/articles/PMC10466790/ /pubmed/37654990 http://dx.doi.org/10.3389/fpsyt.2023.1238973 Text en Copyright © 2023 Jiang, Dang, Nie, Kong, Jiang and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Jiang, Yuwei
Dang, Wenjun
Nie, Hong
Kong, Xiangying
Jiang, Zhimei
Guo, Jin
Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review
title Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review
title_full Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review
title_fullStr Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review
title_full_unstemmed Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review
title_short Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review
title_sort omega-3 polyunsaturated fatty acids and/or vitamin d in autism spectrum disorders: a systematic review
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466790/
https://www.ncbi.nlm.nih.gov/pubmed/37654990
http://dx.doi.org/10.3389/fpsyt.2023.1238973
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