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Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population

BACKGROUND: Pro-oxidant/antioxidant imbalances leading to chronic inflammation and insulin resistance can contribute to the development of metabolic syndrome (MetS). Oxidative Balance Score (OBS), a comprehensive measure of exposure to pro- and anti-oxidants, represents an individual’s total oxidati...

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Autores principales: Park, Hye-Min, Han, Tea-Hwa, Kwon, Yu-Jin, Lee, Jun-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466805/
https://www.ncbi.nlm.nih.gov/pubmed/37654473
http://dx.doi.org/10.3389/fnut.2023.1226107
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author Park, Hye-Min
Han, Tea-Hwa
Kwon, Yu-Jin
Lee, Jun-Hyuk
author_facet Park, Hye-Min
Han, Tea-Hwa
Kwon, Yu-Jin
Lee, Jun-Hyuk
author_sort Park, Hye-Min
collection PubMed
description BACKGROUND: Pro-oxidant/antioxidant imbalances leading to chronic inflammation and insulin resistance can contribute to the development of metabolic syndrome (MetS). Oxidative Balance Score (OBS), a comprehensive measure of exposure to pro- and anti-oxidants, represents an individual’s total oxidative balance. This study aimed to evaluate the association between OBS and MetS using two large datasets. METHODS: We analyzed data from 2,735 adults older than 19 years from the 2021 Korean National Health and Nutritional Examination Survey (KNHANES) and 5,807 adults aged 40–69 years from the Korean Genome and Epidemiology Study (KoGES). In each dataset, OBS was categorized into sex-specific tertiles (T). RESULTS: In KNHANES, the odds ratios and 95% confidence intervals for prevalent MetS in T3, compared to T1, were 0.44 (0.29–0.65) in men and 0.34 (0.23–0.50) in women after adjusting for confounders. In KoGES, the hazard ratios and 95% confidence intervals for incident MetS in T3, compared to T1, were 0.56 (0.48–0.65) in men and 0.63 (0.55–0.73) in women after adjusting for confounders. CONCLUSION: OBS appears to be inversely related to MetS, which suggests that adopting lifestyle behaviors that decrease oxidative stress could be an important preventive strategy for MetS.
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spelling pubmed-104668052023-08-31 Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population Park, Hye-Min Han, Tea-Hwa Kwon, Yu-Jin Lee, Jun-Hyuk Front Nutr Nutrition BACKGROUND: Pro-oxidant/antioxidant imbalances leading to chronic inflammation and insulin resistance can contribute to the development of metabolic syndrome (MetS). Oxidative Balance Score (OBS), a comprehensive measure of exposure to pro- and anti-oxidants, represents an individual’s total oxidative balance. This study aimed to evaluate the association between OBS and MetS using two large datasets. METHODS: We analyzed data from 2,735 adults older than 19 years from the 2021 Korean National Health and Nutritional Examination Survey (KNHANES) and 5,807 adults aged 40–69 years from the Korean Genome and Epidemiology Study (KoGES). In each dataset, OBS was categorized into sex-specific tertiles (T). RESULTS: In KNHANES, the odds ratios and 95% confidence intervals for prevalent MetS in T3, compared to T1, were 0.44 (0.29–0.65) in men and 0.34 (0.23–0.50) in women after adjusting for confounders. In KoGES, the hazard ratios and 95% confidence intervals for incident MetS in T3, compared to T1, were 0.56 (0.48–0.65) in men and 0.63 (0.55–0.73) in women after adjusting for confounders. CONCLUSION: OBS appears to be inversely related to MetS, which suggests that adopting lifestyle behaviors that decrease oxidative stress could be an important preventive strategy for MetS. Frontiers Media S.A. 2023-08-16 /pmc/articles/PMC10466805/ /pubmed/37654473 http://dx.doi.org/10.3389/fnut.2023.1226107 Text en Copyright © 2023 Park, Han, Kwon and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Park, Hye-Min
Han, Tea-Hwa
Kwon, Yu-Jin
Lee, Jun-Hyuk
Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population
title Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population
title_full Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population
title_fullStr Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population
title_full_unstemmed Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population
title_short Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population
title_sort oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the korean population
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466805/
https://www.ncbi.nlm.nih.gov/pubmed/37654473
http://dx.doi.org/10.3389/fnut.2023.1226107
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