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Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease

The H6N2 subtype avian influenza virus (AIV) is commonly detected in the migratory waterfowl reservoirs. Previously, H6N2 AIV was believed to be nonpathogenic to young chickens and could not infect or shed in their respiratory tract under experimental conditions. However, in present study, a highly...

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Autores principales: Dong, Meng-Yi, Guo, Zhong-Wei, Li, Yong-Xin, Lv, Jia-Dai, Xiang, Xue-Lian, Cui, Min, Han, Xin-Feng, Cao, San-Jie, Huang, Yong, Xia, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466914/
https://www.ncbi.nlm.nih.gov/pubmed/37611454
http://dx.doi.org/10.1016/j.psj.2023.103012
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author Dong, Meng-Yi
Guo, Zhong-Wei
Li, Yong-Xin
Lv, Jia-Dai
Xiang, Xue-Lian
Cui, Min
Han, Xin-Feng
Cao, San-Jie
Huang, Yong
Xia, Jing
author_facet Dong, Meng-Yi
Guo, Zhong-Wei
Li, Yong-Xin
Lv, Jia-Dai
Xiang, Xue-Lian
Cui, Min
Han, Xin-Feng
Cao, San-Jie
Huang, Yong
Xia, Jing
author_sort Dong, Meng-Yi
collection PubMed
description The H6N2 subtype avian influenza virus (AIV) is commonly detected in the migratory waterfowl reservoirs. Previously, H6N2 AIV was believed to be nonpathogenic to young chickens and could not infect or shed in their respiratory tract under experimental conditions. However, in present study, a highly recombinant strain of duck-derived H6N2 AIV was discovered and isolated for pathogenicity tests. The results revealed that H6N2 could induce seroconversion in chickens and high morbidity of over 86.7%, along with evident upper respiratory tract hemorrhage. Moreover, 5 substitutions were detected in the upper respiratory tract shedding reisolated virus, with a high viral load in the target organs of infected chickens. In contrast, ducks failed to exhibit any symptoms, pathological lesions, or viral shedding, while demonstrated seroconversion and high viral load in the livers. These findings indicate that H6N2 AIV could also show pathogenicity to chickens under experimental conditions, thereby effectively replicating and shedding in chickens. Therefore, the study provides further elucidations on the pathogenicity of H6N2 AIV.
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spelling pubmed-104669142023-08-31 Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease Dong, Meng-Yi Guo, Zhong-Wei Li, Yong-Xin Lv, Jia-Dai Xiang, Xue-Lian Cui, Min Han, Xin-Feng Cao, San-Jie Huang, Yong Xia, Jing Poult Sci IMMUNOLOGY, HEALTH AND DISEASE The H6N2 subtype avian influenza virus (AIV) is commonly detected in the migratory waterfowl reservoirs. Previously, H6N2 AIV was believed to be nonpathogenic to young chickens and could not infect or shed in their respiratory tract under experimental conditions. However, in present study, a highly recombinant strain of duck-derived H6N2 AIV was discovered and isolated for pathogenicity tests. The results revealed that H6N2 could induce seroconversion in chickens and high morbidity of over 86.7%, along with evident upper respiratory tract hemorrhage. Moreover, 5 substitutions were detected in the upper respiratory tract shedding reisolated virus, with a high viral load in the target organs of infected chickens. In contrast, ducks failed to exhibit any symptoms, pathological lesions, or viral shedding, while demonstrated seroconversion and high viral load in the livers. These findings indicate that H6N2 AIV could also show pathogenicity to chickens under experimental conditions, thereby effectively replicating and shedding in chickens. Therefore, the study provides further elucidations on the pathogenicity of H6N2 AIV. Elsevier 2023-08-09 /pmc/articles/PMC10466914/ /pubmed/37611454 http://dx.doi.org/10.1016/j.psj.2023.103012 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle IMMUNOLOGY, HEALTH AND DISEASE
Dong, Meng-Yi
Guo, Zhong-Wei
Li, Yong-Xin
Lv, Jia-Dai
Xiang, Xue-Lian
Cui, Min
Han, Xin-Feng
Cao, San-Jie
Huang, Yong
Xia, Jing
Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease
title Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease
title_full Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease
title_fullStr Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease
title_full_unstemmed Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease
title_short Research Note: A recombinant duck-derived H6N2 subtype avian influenza virus can replicate and shed in young chickens and cause disease
title_sort research note: a recombinant duck-derived h6n2 subtype avian influenza virus can replicate and shed in young chickens and cause disease
topic IMMUNOLOGY, HEALTH AND DISEASE
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466914/
https://www.ncbi.nlm.nih.gov/pubmed/37611454
http://dx.doi.org/10.1016/j.psj.2023.103012
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