Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain

Protonation of key histidine residues has been long implicated in the acid-mediated cellular action of the diphtheria toxin translocation (T-) domain, responsible for the delivery of the catalytic domain into the cell. Here, we use a combination of computational (constant-pH Molecular Dynamics simul...

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Detalles Bibliográficos
Autores principales: Rodnin, Mykola V., Vasques-Montes, Victor, Kyrychenko, Alexander, Oliveira, Nuno F. B., Kashipathy, Maithri M., Battaile, Kevin P., Douglas, Justin, Lovell, Scott, Machuqueiro, Miguel, Ladokhin, Alexey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467104/
https://www.ncbi.nlm.nih.gov/pubmed/37505680
http://dx.doi.org/10.3390/toxins15070410

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