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Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance

BACKGROUND: Hyperhomocysteinemia is an emerging risk factor causing early-onset cardiovascular events. The objective of the study was to assess serum homocysteine levels in newly diagnosed young persons (age < 30 years) with abnormal glucose tolerance. METHODOLOGY: This cross-sectional study incl...

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Autores principales: Rijal, Amrit, Sultana, Nusrat, Hasan, Mashfiqul, Morshed, Md Shahed, Hasanat, Muhammad Abul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467175/
https://www.ncbi.nlm.nih.gov/pubmed/37655304
http://dx.doi.org/10.1177/20503121231195602
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author Rijal, Amrit
Sultana, Nusrat
Hasan, Mashfiqul
Morshed, Md Shahed
Hasanat, Muhammad Abul
author_facet Rijal, Amrit
Sultana, Nusrat
Hasan, Mashfiqul
Morshed, Md Shahed
Hasanat, Muhammad Abul
author_sort Rijal, Amrit
collection PubMed
description BACKGROUND: Hyperhomocysteinemia is an emerging risk factor causing early-onset cardiovascular events. The objective of the study was to assess serum homocysteine levels in newly diagnosed young persons (age < 30 years) with abnormal glucose tolerance. METHODOLOGY: This cross-sectional study included 40 young participants with newly diagnosed abnormal glucose tolerance (including prediabetes and diabetes mellitus) and an equal number of young persons with normal glucose tolerance (normal glucose tolerance vs prediabetes vs. diabetes mellitus-age (years): 25.0 (22.0, 28.0) vs 25.50 (21.50, 27.0) vs 28.0 (25.0, 29.0), median (interquartile range)). Glycemic status was diagnosed by American Diabetes Association, 2021 criteria. After taking clinical information, fasting blood was collected to measure homocysteine by chemiluminescent immunoassay. RESULTS: Homocysteine level was different across the spectrum of glycemic status (normal glucose tolerance vs. prediabetes vs. diabetes mellitus: 15.57 (13.89–20.71) vs 13.19 (11.40–18.11) vs 12.27 (9.97–14.42) µmol/L; median (interquartile range); p = 0.006). Serum homocysteine was significantly elevated in participants with normal glucose tolerance than diabetes mellitus (p = 0.006) but statistically similar in prediabetes in comparison to both normal glucose tolerance and diabetes mellitus (p = NS for both). Homocysteine level was above the normal level in 47.5% of participants with normal glucose tolerance and in 22.5% with abnormal glucose tolerance (p = 0.019). CONCLUSIONS: Patients under 30 years with diabetes mellitus had lower homocysteine levels than those with normal glucose tolerance.
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spelling pubmed-104671752023-08-31 Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance Rijal, Amrit Sultana, Nusrat Hasan, Mashfiqul Morshed, Md Shahed Hasanat, Muhammad Abul SAGE Open Med Original Article BACKGROUND: Hyperhomocysteinemia is an emerging risk factor causing early-onset cardiovascular events. The objective of the study was to assess serum homocysteine levels in newly diagnosed young persons (age < 30 years) with abnormal glucose tolerance. METHODOLOGY: This cross-sectional study included 40 young participants with newly diagnosed abnormal glucose tolerance (including prediabetes and diabetes mellitus) and an equal number of young persons with normal glucose tolerance (normal glucose tolerance vs prediabetes vs. diabetes mellitus-age (years): 25.0 (22.0, 28.0) vs 25.50 (21.50, 27.0) vs 28.0 (25.0, 29.0), median (interquartile range)). Glycemic status was diagnosed by American Diabetes Association, 2021 criteria. After taking clinical information, fasting blood was collected to measure homocysteine by chemiluminescent immunoassay. RESULTS: Homocysteine level was different across the spectrum of glycemic status (normal glucose tolerance vs. prediabetes vs. diabetes mellitus: 15.57 (13.89–20.71) vs 13.19 (11.40–18.11) vs 12.27 (9.97–14.42) µmol/L; median (interquartile range); p = 0.006). Serum homocysteine was significantly elevated in participants with normal glucose tolerance than diabetes mellitus (p = 0.006) but statistically similar in prediabetes in comparison to both normal glucose tolerance and diabetes mellitus (p = NS for both). Homocysteine level was above the normal level in 47.5% of participants with normal glucose tolerance and in 22.5% with abnormal glucose tolerance (p = 0.019). CONCLUSIONS: Patients under 30 years with diabetes mellitus had lower homocysteine levels than those with normal glucose tolerance. SAGE Publications 2023-08-27 /pmc/articles/PMC10467175/ /pubmed/37655304 http://dx.doi.org/10.1177/20503121231195602 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Rijal, Amrit
Sultana, Nusrat
Hasan, Mashfiqul
Morshed, Md Shahed
Hasanat, Muhammad Abul
Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance
title Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance
title_full Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance
title_fullStr Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance
title_full_unstemmed Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance
title_short Serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance
title_sort serum homocysteine level in newly diagnosed young patients with abnormal glucose tolerance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467175/
https://www.ncbi.nlm.nih.gov/pubmed/37655304
http://dx.doi.org/10.1177/20503121231195602
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