Citrullinated and malondialdehyde-acetaldehyde modified fibrinogen activates macrophages and promotes an aggressive synovial fibroblast phenotype in patients with rheumatoid arthritis

OBJECTIVE: Post-translational protein modifications with malondialdehyde-acetaldehyde (MAA) and citrulline (CIT) are implicated in the pathogenesis of rheumatoid arthritis (RA). Although precise mechanisms have not been elucidated, macrophage-fibroblast interactions have been proposed to play a cent...

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Detalles Bibliográficos
Autores principales: Aripova, Nozima, Duryee, Michael J., England, Bryant R., Hunter, Carlos D., Mordeson, Jack E., Ryan, Evan M., Daubach, Eric C., Romberger, Debra J., Thiele, Geoffrey M., Mikuls, Ted R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467288/
https://www.ncbi.nlm.nih.gov/pubmed/37654483
http://dx.doi.org/10.3389/fimmu.2023.1203548

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