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Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy
Sepsis-induced coagulopathy (SIC) is a life-threatening complication characterized by the systemic activation of coagulation in sepsis. The diagnostic criteria of SIC consist of three items, including Sequential Organ Failure Assessment (SOFA) score, platelet count, and prothrombin time (PT)-interna...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467369/ https://www.ncbi.nlm.nih.gov/pubmed/37605466 http://dx.doi.org/10.1177/10760296231195089 |
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author | Li, Yuting Li, Hongxiang Wang, Youquan Guo, Jianxing Zhang, Dong |
author_facet | Li, Yuting Li, Hongxiang Wang, Youquan Guo, Jianxing Zhang, Dong |
author_sort | Li, Yuting |
collection | PubMed |
description | Sepsis-induced coagulopathy (SIC) is a life-threatening complication characterized by the systemic activation of coagulation in sepsis. The diagnostic criteria of SIC consist of three items, including Sequential Organ Failure Assessment (SOFA) score, platelet count, and prothrombin time (PT)-international normalized ratio (INR). SIC has a high prevalence and it can lead to a higher mortality rate and longer length of hospital and ICU stay. Thus, the early detection of SIC is extremely important. It is unfortunate that there is still no precise biomarker for early diagnosis and assessment of the prognosis of SIC. We reviewed the current literature and discovered that some potential biomarkers, such as soluble thrombomodulin (sTM), thrombin–antithrombin complex (TAT), tissue plasminogen activator-inhibitor complex (t-PAIC), α2-plasmin inhibitor-plasmin complex (PIC), C-type lectin-like receptor 2 (CLEC-2), neutrophil extracellular traps (NETs), prothrombin fragment 1.2 (F1.2), Angiopoietin-2 (Ang-2), plasminogen activator inhibitor-1 (PAI-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) may be useful for early diagnosis, evaluation, and prognosis of SIC. Early initiation of treatment without missing any therapeutic opportunities may improve SIC patients’ prognosis. Further large-scale clinical studies are still needed to confirm the role of these biomarkers in the diagnosis and prognosis assessment of SIC. |
format | Online Article Text |
id | pubmed-10467369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-104673692023-08-31 Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy Li, Yuting Li, Hongxiang Wang, Youquan Guo, Jianxing Zhang, Dong Clin Appl Thromb Hemost Review Sepsis-induced coagulopathy (SIC) is a life-threatening complication characterized by the systemic activation of coagulation in sepsis. The diagnostic criteria of SIC consist of three items, including Sequential Organ Failure Assessment (SOFA) score, platelet count, and prothrombin time (PT)-international normalized ratio (INR). SIC has a high prevalence and it can lead to a higher mortality rate and longer length of hospital and ICU stay. Thus, the early detection of SIC is extremely important. It is unfortunate that there is still no precise biomarker for early diagnosis and assessment of the prognosis of SIC. We reviewed the current literature and discovered that some potential biomarkers, such as soluble thrombomodulin (sTM), thrombin–antithrombin complex (TAT), tissue plasminogen activator-inhibitor complex (t-PAIC), α2-plasmin inhibitor-plasmin complex (PIC), C-type lectin-like receptor 2 (CLEC-2), neutrophil extracellular traps (NETs), prothrombin fragment 1.2 (F1.2), Angiopoietin-2 (Ang-2), plasminogen activator inhibitor-1 (PAI-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) may be useful for early diagnosis, evaluation, and prognosis of SIC. Early initiation of treatment without missing any therapeutic opportunities may improve SIC patients’ prognosis. Further large-scale clinical studies are still needed to confirm the role of these biomarkers in the diagnosis and prognosis assessment of SIC. SAGE Publications 2023-08-21 /pmc/articles/PMC10467369/ /pubmed/37605466 http://dx.doi.org/10.1177/10760296231195089 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Li, Yuting Li, Hongxiang Wang, Youquan Guo, Jianxing Zhang, Dong Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy |
title | Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of
Sepsis-Induced Coagulopathy |
title_full | Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of
Sepsis-Induced Coagulopathy |
title_fullStr | Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of
Sepsis-Induced Coagulopathy |
title_full_unstemmed | Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of
Sepsis-Induced Coagulopathy |
title_short | Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of
Sepsis-Induced Coagulopathy |
title_sort | potential biomarkers for early diagnosis, evaluation, and prognosis of
sepsis-induced coagulopathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467369/ https://www.ncbi.nlm.nih.gov/pubmed/37605466 http://dx.doi.org/10.1177/10760296231195089 |
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