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Chemical probes and methods for the study of protein arginine methylation
Protein arginine methylation is a widespread post-translational modification (PTM) in eukaryotic cells. This chemical modification in proteins functionally modulates diverse cellular processes from signal transduction, gene expression, and DNA damage repair to RNA splicing. The chemistry of arginine...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467615/ https://www.ncbi.nlm.nih.gov/pubmed/37654509 http://dx.doi.org/10.1039/d3cb00018d |
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author | Brown, Tyler Nguyen, Terry Zhou, Bo Zheng, Y. George |
author_facet | Brown, Tyler Nguyen, Terry Zhou, Bo Zheng, Y. George |
author_sort | Brown, Tyler |
collection | PubMed |
description | Protein arginine methylation is a widespread post-translational modification (PTM) in eukaryotic cells. This chemical modification in proteins functionally modulates diverse cellular processes from signal transduction, gene expression, and DNA damage repair to RNA splicing. The chemistry of arginine methylation entails the transfer of the methyl group from S-adenosyl-l-methionine (AdoMet, SAM) onto a guanidino nitrogen atom of an arginine residue of a target protein. This reaction is catalyzed by about 10 members of protein arginine methyltransferases (PRMTs). With impacts on a variety of cellular processes, aberrant expression and activity of PRMTs have been shown in many disease conditions. Particularly in oncology, PRMTs are commonly overexpressed in many cancerous tissues and positively correlated with tumor initiation, development and progression. As such, targeting PRMTs is increasingly recognized as an appealing therapeutic strategy for new drug discovery. In the past decade, a great deal of research efforts has been invested in illuminating PRMT functions in diseases and developing chemical probes for the mechanistic study of PRMTs in biological systems. In this review, we provide a brief developmental history of arginine methylation along with some key updates in arginine methylation research, with a particular emphasis on the chemical aspects of arginine methylation. We highlight the research endeavors for the development and application of chemical approaches and chemical tools for the study of functions of PRMTs and arginine methylation in regulating biology and disease. |
format | Online Article Text |
id | pubmed-10467615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | RSC |
record_format | MEDLINE/PubMed |
spelling | pubmed-104676152023-08-31 Chemical probes and methods for the study of protein arginine methylation Brown, Tyler Nguyen, Terry Zhou, Bo Zheng, Y. George RSC Chem Biol Chemistry Protein arginine methylation is a widespread post-translational modification (PTM) in eukaryotic cells. This chemical modification in proteins functionally modulates diverse cellular processes from signal transduction, gene expression, and DNA damage repair to RNA splicing. The chemistry of arginine methylation entails the transfer of the methyl group from S-adenosyl-l-methionine (AdoMet, SAM) onto a guanidino nitrogen atom of an arginine residue of a target protein. This reaction is catalyzed by about 10 members of protein arginine methyltransferases (PRMTs). With impacts on a variety of cellular processes, aberrant expression and activity of PRMTs have been shown in many disease conditions. Particularly in oncology, PRMTs are commonly overexpressed in many cancerous tissues and positively correlated with tumor initiation, development and progression. As such, targeting PRMTs is increasingly recognized as an appealing therapeutic strategy for new drug discovery. In the past decade, a great deal of research efforts has been invested in illuminating PRMT functions in diseases and developing chemical probes for the mechanistic study of PRMTs in biological systems. In this review, we provide a brief developmental history of arginine methylation along with some key updates in arginine methylation research, with a particular emphasis on the chemical aspects of arginine methylation. We highlight the research endeavors for the development and application of chemical approaches and chemical tools for the study of functions of PRMTs and arginine methylation in regulating biology and disease. RSC 2023-07-28 /pmc/articles/PMC10467615/ /pubmed/37654509 http://dx.doi.org/10.1039/d3cb00018d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Brown, Tyler Nguyen, Terry Zhou, Bo Zheng, Y. George Chemical probes and methods for the study of protein arginine methylation |
title | Chemical probes and methods for the study of protein arginine methylation |
title_full | Chemical probes and methods for the study of protein arginine methylation |
title_fullStr | Chemical probes and methods for the study of protein arginine methylation |
title_full_unstemmed | Chemical probes and methods for the study of protein arginine methylation |
title_short | Chemical probes and methods for the study of protein arginine methylation |
title_sort | chemical probes and methods for the study of protein arginine methylation |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467615/ https://www.ncbi.nlm.nih.gov/pubmed/37654509 http://dx.doi.org/10.1039/d3cb00018d |
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