Discovery of cisplatin-binding proteins by competitive cysteinome profiling

Cisplatin is a widely used cancer metallodrug that induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was ide...

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Detalles Bibliográficos
Autores principales: Wang, Xianghe, Zhang, Yihai, Wang, Chu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467758/
https://www.ncbi.nlm.nih.gov/pubmed/37654507
http://dx.doi.org/10.1039/d3cb00042g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467758/
https://www.ncbi.nlm.nih.gov/pubmed/37654507
http://dx.doi.org/10.1039/d3cb00042g

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