Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition

BACKGROUND: We have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile acid and sterol signaling and transport. In the...

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Detalles Bibliográficos
Autores principales: Shearn, Colin T., Anderson, Aimee L., Devereaux, Michael W., El Kasmi, Karim C., Orlicky, David J., Sokol, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468060/
https://www.ncbi.nlm.nih.gov/pubmed/37647292
http://dx.doi.org/10.1371/journal.pone.0290385

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