Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels

In myelinating Schwann cells, connection between myelin layers is mediated by gap junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs). Mutations in Cx32 cause the X-linked Charcot-Marie-Tooth disease (CMT1X), a degenerative neuropathy without a cure. A molecular link betw...

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Detalles Bibliográficos
Autores principales: Qi, Chao, Lavriha, Pia, Bayraktar, Erva, Vaithia, Anand, Schuster, Dina, Pannella, Micaela, Sala, Valentina, Picotti, Paola, Bortolozzi, Mario, Korkhov, Volodymyr M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468125/
https://www.ncbi.nlm.nih.gov/pubmed/37647412
http://dx.doi.org/10.1126/sciadv.adh4890

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