Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells

Intestinal stem cell (ISC) is a promising therapeutic target for inflammatory bowel disease. Cholesterol availability is critical for ISC stemness. Low plasma cholesterol is a typical feature of Crohn’s disease (CD); however, its impact on mucosal healing remains unclear. Here, we identified an esse...

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Detalles Bibliográficos
Autores principales: Bao, Weilian, You, Yan, Ni, Jiahui, Hou, Hui, Lyu, Jiaren, Feng, Guize, Wang, Yirui, You, Keyuan, Zhang, Sulin, Zhang, Lijie, Cao, Xinyue, Wang, Xu, Li, Haidong, Li, Hong, Xu, Jiake, Liu, Chenying, Luo, Xiaomin, Du, Peng, Chen, Daofeng, Shen, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468130/
https://www.ncbi.nlm.nih.gov/pubmed/37647408
http://dx.doi.org/10.1126/sciadv.adh5016

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