A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

When replication forks encounter DNA lesions that cause polymerase stalling, a checkpoint pathway is activated. The ATR-dependent intra-S checkpoint pathway mediates detection and processing of sites of replication fork stalling to maintain genomic integrity. Several factors involved in the global c...

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Detalles Bibliográficos
Autores principales: Ahmed-Seghir, Sana, Jalan, Manisha, Grimsley, Helen E, Sharma, Aman, Twayana, Shyam, Kosiyatrakul, Settapong T, Thompson, Christopher, Schildkraut, Carl L, Powell, Simon N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468204/
https://www.ncbi.nlm.nih.gov/pubmed/37647215
http://dx.doi.org/10.7554/eLife.87357

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