Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects

Splenectomy improves the clinical parameters of patients with hereditary spherocytosis, but its potential benefit to red blood cell (RBC) functionality and the mechanism behind this benefit remain largely overlooked. Here, we compared 7 nonsplenectomized and 13 splenectomized patients with mutations...

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Detalles Bibliográficos
Autores principales: Cloos, Anne-Sophie, Pollet, Hélène, Stommen, Amaury, Maja, Mauriane, Lingurski, Maxime, Brichard, Bénédicte, Lambert, Catherine, Henriet, Patrick, Pierreux, Christophe, Pyr dit Ruys, Sébastien, Van Der Smissen, Patrick, Vikkula, Miikka, Gatto, Laurent, Martin, Manon, Brouillard, Pascal, Vertommen, Didier, Tyteca, Donatienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468371/
https://www.ncbi.nlm.nih.gov/pubmed/36753606
http://dx.doi.org/10.1182/bloodadvances.2022009114

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