Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment

Mucinous ovarian carcinoma (MOC) is a rare histological type of epithelial ovarian cancer. It has poor response to conventional platinum-based chemotherapy regimens and PARPi-based maintenance treatment, resulting in short survival and poor prognosis in advanced-disease patients. MOC is characterize...

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Detalles Bibliográficos
Autores principales: Wang, Yicong, Liu, Lifeng, Yu, Yongai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468386/
https://www.ncbi.nlm.nih.gov/pubmed/37664708
http://dx.doi.org/10.1016/j.heliyon.2023.e19221
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author Wang, Yicong
Liu, Lifeng
Yu, Yongai
author_facet Wang, Yicong
Liu, Lifeng
Yu, Yongai
author_sort Wang, Yicong
collection PubMed
description Mucinous ovarian carcinoma (MOC) is a rare histological type of epithelial ovarian cancer. It has poor response to conventional platinum-based chemotherapy regimens and PARPi-based maintenance treatment, resulting in short survival and poor prognosis in advanced-disease patients. MOC is characterized by mucus that is mainly composed of mucin in the cystic cavity. Our review discusses in detail the role of mucins in MOC. Mucins are correlated with MOC development. Furthermore, they are valuable in the differential diagnosis of primary and secondary ovarian mucinous tumors. Some types of mucins have been studied in the context of chemoresistance and targeted therapy for ovarian cancer. This review may provide a new direction for the diagnosis and treatment of advanced MOC.
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spelling pubmed-104683862023-09-01 Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment Wang, Yicong Liu, Lifeng Yu, Yongai Heliyon Review Article Mucinous ovarian carcinoma (MOC) is a rare histological type of epithelial ovarian cancer. It has poor response to conventional platinum-based chemotherapy regimens and PARPi-based maintenance treatment, resulting in short survival and poor prognosis in advanced-disease patients. MOC is characterized by mucus that is mainly composed of mucin in the cystic cavity. Our review discusses in detail the role of mucins in MOC. Mucins are correlated with MOC development. Furthermore, they are valuable in the differential diagnosis of primary and secondary ovarian mucinous tumors. Some types of mucins have been studied in the context of chemoresistance and targeted therapy for ovarian cancer. This review may provide a new direction for the diagnosis and treatment of advanced MOC. Elsevier 2023-08-17 /pmc/articles/PMC10468386/ /pubmed/37664708 http://dx.doi.org/10.1016/j.heliyon.2023.e19221 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Wang, Yicong
Liu, Lifeng
Yu, Yongai
Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment
title Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment
title_full Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment
title_fullStr Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment
title_full_unstemmed Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment
title_short Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment
title_sort mucins and mucinous ovarian carcinoma: development, differential diagnosis, and treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468386/
https://www.ncbi.nlm.nih.gov/pubmed/37664708
http://dx.doi.org/10.1016/j.heliyon.2023.e19221
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