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Intricacies of TGF-β signaling in Treg and Th17 cell biology

Balanced immunity is pivotal for health and homeostasis. CD4(+) helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens. Dysregulation of Th cell function often leads to maladies, includ...

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Autores principales: Wang, Junying, Zhao, Xingqi, Wan, Yisong Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468540/
https://www.ncbi.nlm.nih.gov/pubmed/37217798
http://dx.doi.org/10.1038/s41423-023-01036-7
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author Wang, Junying
Zhao, Xingqi
Wan, Yisong Y.
author_facet Wang, Junying
Zhao, Xingqi
Wan, Yisong Y.
author_sort Wang, Junying
collection PubMed
description Balanced immunity is pivotal for health and homeostasis. CD4(+) helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens. Dysregulation of Th cell function often leads to maladies, including autoimmunity, inflammatory disease, cancer, and infection. Regulatory T (Treg) and Th17 cells are critical Th cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. It is therefore critical to understand how Treg and Th17 cells are regulated in health and disease. Cytokines are instrumental in directing Treg and Th17 cell function. The evolutionarily conserved TGF-β (transforming growth factor-β) cytokine superfamily is of particular interest because it is central to the biology of both Treg cells that are predominantly immunosuppressive and Th17 cells that can be proinflammatory, pathogenic, and immune regulatory. How TGF-β superfamily members and their intricate signaling pathways regulate Treg and Th17 cell function is a question that has been intensely investigated for two decades. Here, we introduce the fundamental biology of TGF-β superfamily signaling, Treg cells, and Th17 cells and discuss in detail how the TGF-β superfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks.
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spelling pubmed-104685402023-09-01 Intricacies of TGF-β signaling in Treg and Th17 cell biology Wang, Junying Zhao, Xingqi Wan, Yisong Y. Cell Mol Immunol Review Article Balanced immunity is pivotal for health and homeostasis. CD4(+) helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens. Dysregulation of Th cell function often leads to maladies, including autoimmunity, inflammatory disease, cancer, and infection. Regulatory T (Treg) and Th17 cells are critical Th cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. It is therefore critical to understand how Treg and Th17 cells are regulated in health and disease. Cytokines are instrumental in directing Treg and Th17 cell function. The evolutionarily conserved TGF-β (transforming growth factor-β) cytokine superfamily is of particular interest because it is central to the biology of both Treg cells that are predominantly immunosuppressive and Th17 cells that can be proinflammatory, pathogenic, and immune regulatory. How TGF-β superfamily members and their intricate signaling pathways regulate Treg and Th17 cell function is a question that has been intensely investigated for two decades. Here, we introduce the fundamental biology of TGF-β superfamily signaling, Treg cells, and Th17 cells and discuss in detail how the TGF-β superfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks. Nature Publishing Group UK 2023-05-23 2023-09 /pmc/articles/PMC10468540/ /pubmed/37217798 http://dx.doi.org/10.1038/s41423-023-01036-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Junying
Zhao, Xingqi
Wan, Yisong Y.
Intricacies of TGF-β signaling in Treg and Th17 cell biology
title Intricacies of TGF-β signaling in Treg and Th17 cell biology
title_full Intricacies of TGF-β signaling in Treg and Th17 cell biology
title_fullStr Intricacies of TGF-β signaling in Treg and Th17 cell biology
title_full_unstemmed Intricacies of TGF-β signaling in Treg and Th17 cell biology
title_short Intricacies of TGF-β signaling in Treg and Th17 cell biology
title_sort intricacies of tgf-β signaling in treg and th17 cell biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468540/
https://www.ncbi.nlm.nih.gov/pubmed/37217798
http://dx.doi.org/10.1038/s41423-023-01036-7
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