SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice

Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in these drug targets is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein encoded as a small domain at the N terminus of nonstructural pr...

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Detalles Bibliográficos
Autores principales: Alhammad, Yousef M., Parthasarathy, Srivatsan, Ghimire, Roshan, Kerr, Catherine M., O’Connor, Joseph J., Pfannenstiel, Jessica J., Chanda, Debarati, Miller, Caden A., Baumlin, Nathalie, Salathe, Matthias, Unckless, Robert L., Zuñiga, Sonia, Enjuanes, Luis, More, Sunil, Channappanavar, Rudragouda, Fehr, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468617/
https://www.ncbi.nlm.nih.gov/pubmed/37607224
http://dx.doi.org/10.1073/pnas.2302083120

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