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Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2

In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthamide, the target for lethal ADP-ribosylation by diphtheria toxi...

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Detalles Bibliográficos
Autores principales:	Arend, Meike, Ütkür, Koray, Hawer, Harmen, Mayer, Klaus, Ranjan, Namit, Adrian, Lorenz, Brinkmann, Ulrich, Schaffrath, Raffael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shared Science Publishers OG 2023
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468694/ https://www.ncbi.nlm.nih.gov/pubmed/37662670 http://dx.doi.org/10.15698/mic2023.09.804

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