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Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer

PURPOSE: Higher dairy consumption is associated with a lower risk of colorectal cancer (CRC), but no studies thus far have investigated its relation with recurrence in CRC. Few studies have investigated total dairy in relation to mortality in CRC, and yielded inconsistent results. METHODS: In this p...

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Autores principales: van Lanen, Anne-Sophie, Kok, Dieuwertje E., Wesselink, Evertine, Winkels, Renate M., van Halteren, Henk K., de Wilt, Johannes H. W., Kampman, Ellen, van Duijnhoven, Fränzel J. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468734/
https://www.ncbi.nlm.nih.gov/pubmed/37393586
http://dx.doi.org/10.1007/s00394-023-03201-0
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author van Lanen, Anne-Sophie
Kok, Dieuwertje E.
Wesselink, Evertine
Winkels, Renate M.
van Halteren, Henk K.
de Wilt, Johannes H. W.
Kampman, Ellen
van Duijnhoven, Fränzel J. B.
author_facet van Lanen, Anne-Sophie
Kok, Dieuwertje E.
Wesselink, Evertine
Winkels, Renate M.
van Halteren, Henk K.
de Wilt, Johannes H. W.
Kampman, Ellen
van Duijnhoven, Fränzel J. B.
author_sort van Lanen, Anne-Sophie
collection PubMed
description PURPOSE: Higher dairy consumption is associated with a lower risk of colorectal cancer (CRC), but no studies thus far have investigated its relation with recurrence in CRC. Few studies have investigated total dairy in relation to mortality in CRC, and yielded inconsistent results. METHODS: In this prospective cohort study, people newly diagnosed with stage I-III CRC filled out a food frequency questionnaire at diagnosis (n = 1812) and six months after diagnosis (n = 1672). We examined associations between pre- and post-diagnostic intake of total dairy, low-fat dairy, high-fat dairy, milk, yoghurt, and cheese with recurrence and all-cause mortality using multivariable Cox proportional hazard models and restricted cubic splines (RCS). RESULTS: A total of 176 recurrences and 301 deaths occurred during a median follow-up of 3.0 and 5.9 years, respectively. Before diagnosis, a higher low-fat dairy intake was associated with a lower risk of recurrence (HR(Q4vsQ1): 0.42, 95% CI 0.26–0.67; P(RCS): 0.008) and all-cause mortality (HR(Q4vsQ1): 0.58, 95% CI 0.41–0.81; P(RCS) < 0.001), whereas a higher high-fat dairy consumption tended to be associated with an increased all-cause mortality risk (HR(Q4vsQ1): 1.41, 95% CI 0.98–2.01; P(RCS): 0.030). After diagnosis, only the associations between low- and high-fat dairy in relation to all-cause mortality remained. CONCLUSIONS: This study demonstrated that higher pre- and post-diagnostic intakes of low-fat dairy were associated with a reduced all-cause mortality risk in people with stage I-III CRC, whereas higher intakes of high-fat dairy were associated with an increased all-cause mortality risk. Also, a higher pre-diagnostic low-fat dairy intake was associated with a reduced risk of recurrence. TRIAL REGISTRATION: Clinical Trials.gov identifier: NCT03191110. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-023-03201-0.
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spelling pubmed-104687342023-09-01 Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer van Lanen, Anne-Sophie Kok, Dieuwertje E. Wesselink, Evertine Winkels, Renate M. van Halteren, Henk K. de Wilt, Johannes H. W. Kampman, Ellen van Duijnhoven, Fränzel J. B. Eur J Nutr Original Contribution PURPOSE: Higher dairy consumption is associated with a lower risk of colorectal cancer (CRC), but no studies thus far have investigated its relation with recurrence in CRC. Few studies have investigated total dairy in relation to mortality in CRC, and yielded inconsistent results. METHODS: In this prospective cohort study, people newly diagnosed with stage I-III CRC filled out a food frequency questionnaire at diagnosis (n = 1812) and six months after diagnosis (n = 1672). We examined associations between pre- and post-diagnostic intake of total dairy, low-fat dairy, high-fat dairy, milk, yoghurt, and cheese with recurrence and all-cause mortality using multivariable Cox proportional hazard models and restricted cubic splines (RCS). RESULTS: A total of 176 recurrences and 301 deaths occurred during a median follow-up of 3.0 and 5.9 years, respectively. Before diagnosis, a higher low-fat dairy intake was associated with a lower risk of recurrence (HR(Q4vsQ1): 0.42, 95% CI 0.26–0.67; P(RCS): 0.008) and all-cause mortality (HR(Q4vsQ1): 0.58, 95% CI 0.41–0.81; P(RCS) < 0.001), whereas a higher high-fat dairy consumption tended to be associated with an increased all-cause mortality risk (HR(Q4vsQ1): 1.41, 95% CI 0.98–2.01; P(RCS): 0.030). After diagnosis, only the associations between low- and high-fat dairy in relation to all-cause mortality remained. CONCLUSIONS: This study demonstrated that higher pre- and post-diagnostic intakes of low-fat dairy were associated with a reduced all-cause mortality risk in people with stage I-III CRC, whereas higher intakes of high-fat dairy were associated with an increased all-cause mortality risk. Also, a higher pre-diagnostic low-fat dairy intake was associated with a reduced risk of recurrence. TRIAL REGISTRATION: Clinical Trials.gov identifier: NCT03191110. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-023-03201-0. Springer Berlin Heidelberg 2023-07-02 2023 /pmc/articles/PMC10468734/ /pubmed/37393586 http://dx.doi.org/10.1007/s00394-023-03201-0 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Contribution
van Lanen, Anne-Sophie
Kok, Dieuwertje E.
Wesselink, Evertine
Winkels, Renate M.
van Halteren, Henk K.
de Wilt, Johannes H. W.
Kampman, Ellen
van Duijnhoven, Fränzel J. B.
Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
title Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
title_full Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
title_fullStr Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
title_full_unstemmed Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
title_short Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
title_sort pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage i-iii colorectal cancer
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468734/
https://www.ncbi.nlm.nih.gov/pubmed/37393586
http://dx.doi.org/10.1007/s00394-023-03201-0
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