HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model

Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are...

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Detalles Bibliográficos
Autores principales: Cai, Min, Zhu, Yingbo, Shanley, Mary Regis, Morel, Carole, Ku, Stacy M., Zhang, Hongxing, Shen, Yuan, Friedman, Allyson K., Han, Ming-Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468802/
https://www.ncbi.nlm.nih.gov/pubmed/37664876
http://dx.doi.org/10.1016/j.ynstr.2023.100565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468802/
https://www.ncbi.nlm.nih.gov/pubmed/37664876
http://dx.doi.org/10.1016/j.ynstr.2023.100565

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