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HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model
Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468802/ https://www.ncbi.nlm.nih.gov/pubmed/37664876 http://dx.doi.org/10.1016/j.ynstr.2023.100565 |