Novel Canthin-6-one Derivatives: Design, Synthesis, and Their Antiproliferative Activities via Inducing Apoptosis, Deoxyribonucleic Acid Damage, and Ferroptosis

[Image: see text] A series of novel canthin-6-one (CO) derivatives (8a–l) were designed and synthesized by introducing different amide side chains at the C-2 position, and their water solubility, antiproliferative activity, and preliminary mechanism were investigated. Most compounds displayed high c...

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Detalles Bibliográficos
Autores principales: Ding, Jinfeng, Sun, Tiantian, Wu, Hongmei, Zheng, Hongwei, Wang, Sijia, Wang, Dezhi, Shan, Wenpei, Ling, Yong, Zhang, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468838/
https://www.ncbi.nlm.nih.gov/pubmed/37663479
http://dx.doi.org/10.1021/acsomega.3c03358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468838/
https://www.ncbi.nlm.nih.gov/pubmed/37663479
http://dx.doi.org/10.1021/acsomega.3c03358

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