The characteristics and medical applications of antler stem cells

Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same biological features as MSCs, including the capacity for...

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Autores principales: Liu, Qi, Li, Jiannan, Chang, Jinghui, Guo, Yu, Wen, Dacheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468909/
https://www.ncbi.nlm.nih.gov/pubmed/37649124
http://dx.doi.org/10.1186/s13287-023-03456-8
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author Liu, Qi
Li, Jiannan
Chang, Jinghui
Guo, Yu
Wen, Dacheng
author_facet Liu, Qi
Li, Jiannan
Chang, Jinghui
Guo, Yu
Wen, Dacheng
author_sort Liu, Qi
collection PubMed
description Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same biological features as MSCs, including the capacity for self-renewal and multidirectional differentiation, immunomodulatory functions, and the maintenance of stem cell characteristics after multiple passages. Several preclinical studies have shown that ASCs exhibit promising potential in wound healing, bone repair, osteoarthritis, anti-tissue fibrosis, anti-aging, and hair regeneration. Medical applications based on ASCs and ASC-derived molecules provide a new source of stem cells and therapeutic modalities for regenerative medicine. This review begins with a brief description of antler regeneration and the role of ASCs. Then, the properties and advantages of ASCs are described. Finally, medical research advances regarding ASCs are summarized, and the prospects and challenges of ASCs are highlighted.
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spelling pubmed-104689092023-09-01 The characteristics and medical applications of antler stem cells Liu, Qi Li, Jiannan Chang, Jinghui Guo, Yu Wen, Dacheng Stem Cell Res Ther Review Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same biological features as MSCs, including the capacity for self-renewal and multidirectional differentiation, immunomodulatory functions, and the maintenance of stem cell characteristics after multiple passages. Several preclinical studies have shown that ASCs exhibit promising potential in wound healing, bone repair, osteoarthritis, anti-tissue fibrosis, anti-aging, and hair regeneration. Medical applications based on ASCs and ASC-derived molecules provide a new source of stem cells and therapeutic modalities for regenerative medicine. This review begins with a brief description of antler regeneration and the role of ASCs. Then, the properties and advantages of ASCs are described. Finally, medical research advances regarding ASCs are summarized, and the prospects and challenges of ASCs are highlighted. BioMed Central 2023-08-30 /pmc/articles/PMC10468909/ /pubmed/37649124 http://dx.doi.org/10.1186/s13287-023-03456-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Qi
Li, Jiannan
Chang, Jinghui
Guo, Yu
Wen, Dacheng
The characteristics and medical applications of antler stem cells
title The characteristics and medical applications of antler stem cells
title_full The characteristics and medical applications of antler stem cells
title_fullStr The characteristics and medical applications of antler stem cells
title_full_unstemmed The characteristics and medical applications of antler stem cells
title_short The characteristics and medical applications of antler stem cells
title_sort characteristics and medical applications of antler stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468909/
https://www.ncbi.nlm.nih.gov/pubmed/37649124
http://dx.doi.org/10.1186/s13287-023-03456-8
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