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Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres

[Image: see text] The synthesis of calcium carbonate with controlled morphology is crucial for its biomedical applications. In this study, we synthesized well-ordered porous calcium carbonate nanospheres using recombinant collagen as a biomineralization template. Porous collagen-calcium carbonate wa...

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Autores principales: Munyemana, Jean Claude, He, Huixia, Fu, Caihong, Fan, Yirui, Sun, Xiuxia, Xiao, Jianxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468931/
https://www.ncbi.nlm.nih.gov/pubmed/37663506
http://dx.doi.org/10.1021/acsomega.3c01467
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author Munyemana, Jean Claude
He, Huixia
Fu, Caihong
Fan, Yirui
Sun, Xiuxia
Xiao, Jianxi
author_facet Munyemana, Jean Claude
He, Huixia
Fu, Caihong
Fan, Yirui
Sun, Xiuxia
Xiao, Jianxi
author_sort Munyemana, Jean Claude
collection PubMed
description [Image: see text] The synthesis of calcium carbonate with controlled morphology is crucial for its biomedical applications. In this study, we synthesized well-ordered porous calcium carbonate nanospheres using recombinant collagen as a biomineralization template. Porous collagen-calcium carbonate was created by incubating calcium chloride and sodium carbonate with collagen biotemplates at room temperature. Our results show that the recombinant collagen-calcium carbonate nanomaterials underwent a morphological transition from solid nanospheres to more porous nanospheres and a phase transformation from vaterite to a mixture of calcite and vaterite. This study highlights the crucial role of recombinant collagen in modulating the morphology and crystallinity of calcium carbonate nanoparticles. Importantly, the highly porous recombinant collagen-calcium carbonate hybrid nanospheres demonstrated superior loading efficacy for the model drug cefoperazone. Furthermore, the drug loading and releasing results suggest that hybrid nanospheres have the potential to be robust and biocompatible pH-responsive drug carriers. Our findings suggest that recombinant collagen’s unique amino acid content and rodlike structure make it a superior template for biomineralized synthesis. This study provides a promising avenue for the production of novel organic–inorganic nanostructures, with potential applications in biomedical fields such as drug delivery.
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spelling pubmed-104689312023-09-01 Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres Munyemana, Jean Claude He, Huixia Fu, Caihong Fan, Yirui Sun, Xiuxia Xiao, Jianxi ACS Omega [Image: see text] The synthesis of calcium carbonate with controlled morphology is crucial for its biomedical applications. In this study, we synthesized well-ordered porous calcium carbonate nanospheres using recombinant collagen as a biomineralization template. Porous collagen-calcium carbonate was created by incubating calcium chloride and sodium carbonate with collagen biotemplates at room temperature. Our results show that the recombinant collagen-calcium carbonate nanomaterials underwent a morphological transition from solid nanospheres to more porous nanospheres and a phase transformation from vaterite to a mixture of calcite and vaterite. This study highlights the crucial role of recombinant collagen in modulating the morphology and crystallinity of calcium carbonate nanoparticles. Importantly, the highly porous recombinant collagen-calcium carbonate hybrid nanospheres demonstrated superior loading efficacy for the model drug cefoperazone. Furthermore, the drug loading and releasing results suggest that hybrid nanospheres have the potential to be robust and biocompatible pH-responsive drug carriers. Our findings suggest that recombinant collagen’s unique amino acid content and rodlike structure make it a superior template for biomineralized synthesis. This study provides a promising avenue for the production of novel organic–inorganic nanostructures, with potential applications in biomedical fields such as drug delivery. American Chemical Society 2023-08-16 /pmc/articles/PMC10468931/ /pubmed/37663506 http://dx.doi.org/10.1021/acsomega.3c01467 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Munyemana, Jean Claude
He, Huixia
Fu, Caihong
Fan, Yirui
Sun, Xiuxia
Xiao, Jianxi
Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres
title Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres
title_full Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres
title_fullStr Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres
title_full_unstemmed Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres
title_short Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres
title_sort recombinant collagen-templated biomineralized synthesis of biocompatible ph-responsive porous calcium carbonate nanospheres
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468931/
https://www.ncbi.nlm.nih.gov/pubmed/37663506
http://dx.doi.org/10.1021/acsomega.3c01467
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