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Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study
BACKGROUND: Currently, the available evidence regarding the relationship between the lipid profile and Helicobacter pylori (H. pylori) infection is limited and conflicting. There is also a dearth of studies that have explored the possibility of sex-specific differences in the association between H....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468968/ https://www.ncbi.nlm.nih.gov/pubmed/37664839 http://dx.doi.org/10.3389/fendo.2023.1220347 |
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author | Xie, Jun Wang, Jinyun Zeng, Rong Xie, Yong |
author_facet | Xie, Jun Wang, Jinyun Zeng, Rong Xie, Yong |
author_sort | Xie, Jun |
collection | PubMed |
description | BACKGROUND: Currently, the available evidence regarding the relationship between the lipid profile and Helicobacter pylori (H. pylori) infection is limited and conflicting. There is also a dearth of studies that have explored the possibility of sex-specific differences in the association between H. pylori infection and triglyceride levels. METHODS: We conducted a cross-sectional study involving 1,146 participants utilizing data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 conducted in the United States. A logistic regression model was employed to evaluate the association between H. pylori seropositivity and triglyceride levels. Subgroup analyses stratified by sex were conducted to explore sex-specific differences in this association. RESULTS: Serum triglyceride levels were significantly higher in H. pylori-seropositive participants than in H. pylori-seronegative participants. In the logistic regression analysis, there was a positive correlation between H. pylori seropositivity and triglyceride levels (OR=1.231; 95% CI, 1.016-1.491; P=0.033). In the subgroup analysis, the adjusted association between serum triglycerides and H. pylori seropositivity was significant in females (OR=1.732; 95% CI, 1.113-2.696; P=0.015) but not in males (OR=1.091; 95% CI, 0.698-1.705; P=0.704). CONCLUSION: The association between high triglyceride levels and H. pylori infection is specific to the female population. |
format | Online Article Text |
id | pubmed-10468968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104689682023-09-01 Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study Xie, Jun Wang, Jinyun Zeng, Rong Xie, Yong Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Currently, the available evidence regarding the relationship between the lipid profile and Helicobacter pylori (H. pylori) infection is limited and conflicting. There is also a dearth of studies that have explored the possibility of sex-specific differences in the association between H. pylori infection and triglyceride levels. METHODS: We conducted a cross-sectional study involving 1,146 participants utilizing data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 conducted in the United States. A logistic regression model was employed to evaluate the association between H. pylori seropositivity and triglyceride levels. Subgroup analyses stratified by sex were conducted to explore sex-specific differences in this association. RESULTS: Serum triglyceride levels were significantly higher in H. pylori-seropositive participants than in H. pylori-seronegative participants. In the logistic regression analysis, there was a positive correlation between H. pylori seropositivity and triglyceride levels (OR=1.231; 95% CI, 1.016-1.491; P=0.033). In the subgroup analysis, the adjusted association between serum triglycerides and H. pylori seropositivity was significant in females (OR=1.732; 95% CI, 1.113-2.696; P=0.015) but not in males (OR=1.091; 95% CI, 0.698-1.705; P=0.704). CONCLUSION: The association between high triglyceride levels and H. pylori infection is specific to the female population. Frontiers Media S.A. 2023-08-16 /pmc/articles/PMC10468968/ /pubmed/37664839 http://dx.doi.org/10.3389/fendo.2023.1220347 Text en Copyright © 2023 Xie, Wang, Zeng and Xie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Xie, Jun Wang, Jinyun Zeng, Rong Xie, Yong Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study |
title | Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study |
title_full | Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study |
title_fullStr | Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study |
title_full_unstemmed | Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study |
title_short | Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study |
title_sort | association between helicobacter pylori infection and triglyceride levels: a nested cross-sectional study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468968/ https://www.ncbi.nlm.nih.gov/pubmed/37664839 http://dx.doi.org/10.3389/fendo.2023.1220347 |
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