AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line

Non-alcoholic steatohepatitis (NASH) is an aggressive form of fatty liver disease with hepatic inflammation and fibrosis for which there is currently no drug treatment. This study determined whether an indoline derivative, AN1284, which significantly reduced damage in a model of acute liver disease,...

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Autores principales: Yehezkel, Adi S., Abudi, Nathalie, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Weinstock, Marta, Abramovitch, Rinat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469006/
https://www.ncbi.nlm.nih.gov/pubmed/37664863
http://dx.doi.org/10.3389/fendo.2023.1226808

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