Cargando…
The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
BACKGROUND: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO. METHODS: Te...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469024/ https://www.ncbi.nlm.nih.gov/pubmed/37654690 http://dx.doi.org/10.33696/rehabilitation.5.035 |
_version_ | 1785099353698861056 |
---|---|
author | Fazlinejad, Navid Hosseini, Samaneh Yaghoobpoor, Shirin Dehghani, Mina Bazrafshan, Hanieh Khanzadeh, Shokoufeh Lucke-Wold, Brandon |
author_facet | Fazlinejad, Navid Hosseini, Samaneh Yaghoobpoor, Shirin Dehghani, Mina Bazrafshan, Hanieh Khanzadeh, Shokoufeh Lucke-Wold, Brandon |
author_sort | Fazlinejad, Navid |
collection | PubMed |
description | BACKGROUND: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO. METHODS: Ten studies were selected that were sufficiently high quality and then checked for quality. The studies were organized by English language and selective inclusion criteria. RESULTS: NLR was significantly increased in NMO patients compared to controls. The ratio was specifically proportional to severity of disease. More severe disease had a higher ratio. CONCLUSION: NLR offers a reliable and affordable method for early detection of disease severity. This can help guide appropriate treatment selection and monitor treatment response. |
format | Online Article Text |
id | pubmed-10469024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-104690242023-08-31 The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder Fazlinejad, Navid Hosseini, Samaneh Yaghoobpoor, Shirin Dehghani, Mina Bazrafshan, Hanieh Khanzadeh, Shokoufeh Lucke-Wold, Brandon J Phys Med Rehabil Article BACKGROUND: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO. METHODS: Ten studies were selected that were sufficiently high quality and then checked for quality. The studies were organized by English language and selective inclusion criteria. RESULTS: NLR was significantly increased in NMO patients compared to controls. The ratio was specifically proportional to severity of disease. More severe disease had a higher ratio. CONCLUSION: NLR offers a reliable and affordable method for early detection of disease severity. This can help guide appropriate treatment selection and monitor treatment response. 2023 /pmc/articles/PMC10469024/ /pubmed/37654690 http://dx.doi.org/10.33696/rehabilitation.5.035 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Fazlinejad, Navid Hosseini, Samaneh Yaghoobpoor, Shirin Dehghani, Mina Bazrafshan, Hanieh Khanzadeh, Shokoufeh Lucke-Wold, Brandon The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder |
title | The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder |
title_full | The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder |
title_fullStr | The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder |
title_full_unstemmed | The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder |
title_short | The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder |
title_sort | diagnostic value of neutrophil to lymphocyte ratio as an effective biomarker for neuromyelitis optica spectrum disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469024/ https://www.ncbi.nlm.nih.gov/pubmed/37654690 http://dx.doi.org/10.33696/rehabilitation.5.035 |
work_keys_str_mv | AT fazlinejadnavid thediagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT hosseinisamaneh thediagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT yaghoobpoorshirin thediagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT dehghanimina thediagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT bazrafshanhanieh thediagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT khanzadehshokoufeh thediagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT luckewoldbrandon thediagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT fazlinejadnavid diagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT hosseinisamaneh diagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT yaghoobpoorshirin diagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT dehghanimina diagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT bazrafshanhanieh diagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT khanzadehshokoufeh diagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder AT luckewoldbrandon diagnosticvalueofneutrophiltolymphocyteratioasaneffectivebiomarkerforneuromyelitisopticaspectrumdisorder |