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The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder

BACKGROUND: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO. METHODS: Te...

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Autores principales: Fazlinejad, Navid, Hosseini, Samaneh, Yaghoobpoor, Shirin, Dehghani, Mina, Bazrafshan, Hanieh, Khanzadeh, Shokoufeh, Lucke-Wold, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469024/
https://www.ncbi.nlm.nih.gov/pubmed/37654690
http://dx.doi.org/10.33696/rehabilitation.5.035
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author Fazlinejad, Navid
Hosseini, Samaneh
Yaghoobpoor, Shirin
Dehghani, Mina
Bazrafshan, Hanieh
Khanzadeh, Shokoufeh
Lucke-Wold, Brandon
author_facet Fazlinejad, Navid
Hosseini, Samaneh
Yaghoobpoor, Shirin
Dehghani, Mina
Bazrafshan, Hanieh
Khanzadeh, Shokoufeh
Lucke-Wold, Brandon
author_sort Fazlinejad, Navid
collection PubMed
description BACKGROUND: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO. METHODS: Ten studies were selected that were sufficiently high quality and then checked for quality. The studies were organized by English language and selective inclusion criteria. RESULTS: NLR was significantly increased in NMO patients compared to controls. The ratio was specifically proportional to severity of disease. More severe disease had a higher ratio. CONCLUSION: NLR offers a reliable and affordable method for early detection of disease severity. This can help guide appropriate treatment selection and monitor treatment response.
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spelling pubmed-104690242023-08-31 The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder Fazlinejad, Navid Hosseini, Samaneh Yaghoobpoor, Shirin Dehghani, Mina Bazrafshan, Hanieh Khanzadeh, Shokoufeh Lucke-Wold, Brandon J Phys Med Rehabil Article BACKGROUND: Neuromyelitis Optica (NMO) is a serious condition associated with inflammation. Early diagnosis and detection are critical for early intervention. In this systematic review, we investigate the role of the neutrophil to lymphocyte ratio (NLR) as an important biomarker for NMO. METHODS: Ten studies were selected that were sufficiently high quality and then checked for quality. The studies were organized by English language and selective inclusion criteria. RESULTS: NLR was significantly increased in NMO patients compared to controls. The ratio was specifically proportional to severity of disease. More severe disease had a higher ratio. CONCLUSION: NLR offers a reliable and affordable method for early detection of disease severity. This can help guide appropriate treatment selection and monitor treatment response. 2023 /pmc/articles/PMC10469024/ /pubmed/37654690 http://dx.doi.org/10.33696/rehabilitation.5.035 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Fazlinejad, Navid
Hosseini, Samaneh
Yaghoobpoor, Shirin
Dehghani, Mina
Bazrafshan, Hanieh
Khanzadeh, Shokoufeh
Lucke-Wold, Brandon
The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
title The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
title_full The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
title_fullStr The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
title_full_unstemmed The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
title_short The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Neuromyelitis Optica Spectrum Disorder
title_sort diagnostic value of neutrophil to lymphocyte ratio as an effective biomarker for neuromyelitis optica spectrum disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469024/
https://www.ncbi.nlm.nih.gov/pubmed/37654690
http://dx.doi.org/10.33696/rehabilitation.5.035
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