IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding

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The constant domains of antibodies are important for effector functions, but less is known about how they can affect binding and neutralization of viruses. Here, we evaluated a panel of human influenza virus monoclonal antibodies (mAbs) expressed as IgG1, IgG2, or IgG3. We found that many influenza...

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Detalles Bibliográficos
Autores principales: Bolton, Marcus J., Santos, Jefferson J. S., Arevalo, Claudia P., Griesman, Trevor, Watson, Megan, Li, Shuk Hang, Bates, Paul, Ramage, Holly, Wilson, Patrick C., Hensley, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469028/
https://www.ncbi.nlm.nih.gov/pubmed/37603748
http://dx.doi.org/10.1073/pnas.2216521120
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