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Multimodal evaluation of osteosarcoma choroidal metastasis

BACKGROUND: Osteosarcoma (OS) is the most common primary bone carcinoma. Adulthood most frequent intraocular malignant tumor is choroidal metastasis; however, these are rarely related to sarcomas. There are only two OS-related choroidal metastasis cases reported in the literature, both prior to 1970...

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Autores principales: Fernández Mancebo, Federico M., Inga, M. Eugenia, Daich Varela, Malena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469472/
https://www.ncbi.nlm.nih.gov/pubmed/36062609
http://dx.doi.org/10.1177/11206721221123880
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author Fernández Mancebo, Federico M.
Inga, M. Eugenia
Daich Varela, Malena
author_facet Fernández Mancebo, Federico M.
Inga, M. Eugenia
Daich Varela, Malena
author_sort Fernández Mancebo, Federico M.
collection PubMed
description BACKGROUND: Osteosarcoma (OS) is the most common primary bone carcinoma. Adulthood most frequent intraocular malignant tumor is choroidal metastasis; however, these are rarely related to sarcomas. There are only two OS-related choroidal metastasis cases reported in the literature, both prior to 1970. CASE PRESENTATION: A 20-year-old man with a history of tibial OS, right leg amputation, and lung and brain metastases, presented with decreased vision in his right eye (OD). Ophthalmic examination revealed a best-corrected visual acuity of hand movements and a large, posterior pole, nodular, subretinal mass, with associated fluid. B-scan revealed a heterogeneous lump, with medium/high reflectivity, and a height-to-base ratio (HBR) of 1-1.2, approximately. Computerized tomography (CT) scan showed a hyperdense and contrast-enhanced mass, while on magnetic resonance imaging (MRI) the lesion appeared T1-isointense and T2-hypointense. CONCLUSION: Choroidal OS metastasis can appear as a pink nodule with high HBR and intralesional hyperreflective deposits. Sudden visual changes in individuals with OS-related systemic metastatic disease should be monitored closely by ophthalmology and oncology jointly.
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spelling pubmed-104694722023-09-01 Multimodal evaluation of osteosarcoma choroidal metastasis Fernández Mancebo, Federico M. Inga, M. Eugenia Daich Varela, Malena Eur J Ophthalmol Case Reports BACKGROUND: Osteosarcoma (OS) is the most common primary bone carcinoma. Adulthood most frequent intraocular malignant tumor is choroidal metastasis; however, these are rarely related to sarcomas. There are only two OS-related choroidal metastasis cases reported in the literature, both prior to 1970. CASE PRESENTATION: A 20-year-old man with a history of tibial OS, right leg amputation, and lung and brain metastases, presented with decreased vision in his right eye (OD). Ophthalmic examination revealed a best-corrected visual acuity of hand movements and a large, posterior pole, nodular, subretinal mass, with associated fluid. B-scan revealed a heterogeneous lump, with medium/high reflectivity, and a height-to-base ratio (HBR) of 1-1.2, approximately. Computerized tomography (CT) scan showed a hyperdense and contrast-enhanced mass, while on magnetic resonance imaging (MRI) the lesion appeared T1-isointense and T2-hypointense. CONCLUSION: Choroidal OS metastasis can appear as a pink nodule with high HBR and intralesional hyperreflective deposits. Sudden visual changes in individuals with OS-related systemic metastatic disease should be monitored closely by ophthalmology and oncology jointly. SAGE Publications 2022-09-04 2023-09 /pmc/articles/PMC10469472/ /pubmed/36062609 http://dx.doi.org/10.1177/11206721221123880 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Fernández Mancebo, Federico M.
Inga, M. Eugenia
Daich Varela, Malena
Multimodal evaluation of osteosarcoma choroidal metastasis
title Multimodal evaluation of osteosarcoma choroidal metastasis
title_full Multimodal evaluation of osteosarcoma choroidal metastasis
title_fullStr Multimodal evaluation of osteosarcoma choroidal metastasis
title_full_unstemmed Multimodal evaluation of osteosarcoma choroidal metastasis
title_short Multimodal evaluation of osteosarcoma choroidal metastasis
title_sort multimodal evaluation of osteosarcoma choroidal metastasis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469472/
https://www.ncbi.nlm.nih.gov/pubmed/36062609
http://dx.doi.org/10.1177/11206721221123880
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