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GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease

BACKGROUND: Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and associated with poor clinical outcomes. We evaluated the diagnostic validity of growth differentiation factor-15 (GDF-15) and hepcidin as it is not clear if they are useful as a biomarkers of anae...

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Autores principales: Farag, Naglaa Makram, Mousa, Mahmoud, Elsayed, Eman, Ismeil, Ahlam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469522/
https://www.ncbi.nlm.nih.gov/pubmed/37649102
http://dx.doi.org/10.1186/s13052-023-01505-9
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author Farag, Naglaa Makram
Mousa, Mahmoud
Elsayed, Eman
Ismeil, Ahlam
author_facet Farag, Naglaa Makram
Mousa, Mahmoud
Elsayed, Eman
Ismeil, Ahlam
author_sort Farag, Naglaa Makram
collection PubMed
description BACKGROUND: Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and associated with poor clinical outcomes. We evaluated the diagnostic validity of growth differentiation factor-15 (GDF-15) and hepcidin as it is not clear if they are useful as a biomarkers of anaemia among non-dialysis CKD egyptian patients. METHOD: An analytical cross-sectional study was conducted among non-dialysis CKD patients (n = 60) and apparently healthy controls (n = 28) at Minia University maternity & children Hospital. Serum levels of GDF-15 and hepcidin were determined. Predictive logistic regression models were built and post estimation receiver operator characteristics were determined to evaluate diagnostic validity of hepcidin and GDF-15 for iron deficiency anaemia. RESULTS: Hepcidin and GDF-15 are significantly higher in cases than control p value (0.047 < 0.0001) respectively. The predictive value of diagnosing anaemia among CKD patients using hepcidin and GDF-15 was 72.0%, 70.0%. There was a weak negative correlation between hepcidin levels and glomerular filtration rate GFR (r = -.175, p = 0.105) in CKD patients, and significant correlation between serum GDF-15 and haemoglobin (r = -0.897, p < 0.0001), ferritin (r = 0.489, P < 0.000), Iron (r = -0.314, P = 0.002), CRP (r = 0.409, P < 0.0001). CONCLUSION: Hepcidin and GDF-15 is a potential biomarker for predicting anaemia connected with inflammation among CKD Egyptian patients.
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spelling pubmed-104695222023-09-01 GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease Farag, Naglaa Makram Mousa, Mahmoud Elsayed, Eman Ismeil, Ahlam Ital J Pediatr Research BACKGROUND: Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and associated with poor clinical outcomes. We evaluated the diagnostic validity of growth differentiation factor-15 (GDF-15) and hepcidin as it is not clear if they are useful as a biomarkers of anaemia among non-dialysis CKD egyptian patients. METHOD: An analytical cross-sectional study was conducted among non-dialysis CKD patients (n = 60) and apparently healthy controls (n = 28) at Minia University maternity & children Hospital. Serum levels of GDF-15 and hepcidin were determined. Predictive logistic regression models were built and post estimation receiver operator characteristics were determined to evaluate diagnostic validity of hepcidin and GDF-15 for iron deficiency anaemia. RESULTS: Hepcidin and GDF-15 are significantly higher in cases than control p value (0.047 < 0.0001) respectively. The predictive value of diagnosing anaemia among CKD patients using hepcidin and GDF-15 was 72.0%, 70.0%. There was a weak negative correlation between hepcidin levels and glomerular filtration rate GFR (r = -.175, p = 0.105) in CKD patients, and significant correlation between serum GDF-15 and haemoglobin (r = -0.897, p < 0.0001), ferritin (r = 0.489, P < 0.000), Iron (r = -0.314, P = 0.002), CRP (r = 0.409, P < 0.0001). CONCLUSION: Hepcidin and GDF-15 is a potential biomarker for predicting anaemia connected with inflammation among CKD Egyptian patients. BioMed Central 2023-08-30 /pmc/articles/PMC10469522/ /pubmed/37649102 http://dx.doi.org/10.1186/s13052-023-01505-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Farag, Naglaa Makram
Mousa, Mahmoud
Elsayed, Eman
Ismeil, Ahlam
GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
title GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
title_full GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
title_fullStr GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
title_full_unstemmed GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
title_short GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
title_sort gdf-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469522/
https://www.ncbi.nlm.nih.gov/pubmed/37649102
http://dx.doi.org/10.1186/s13052-023-01505-9
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