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Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease

The HIV-1 protease is one of several common key targets of combination drug therapies for human immunodeficiency virus infection and acquired immunodeficiency syndrome. During the progression of the disease, some individual patients acquire drug resistance due to mutational hotspots on the viral pro...

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Detalles Bibliográficos
Autores principales:	Rajendran, Madhusudan, Ferran, Maureen C., Mouli, Leora, Babbitt, Gregory A., Lynch, Miranda L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469570/ https://www.ncbi.nlm.nih.gov/pubmed/37662576 http://dx.doi.org/10.1016/j.bpr.2023.100121

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