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Arterial stiffness is associated with cancer mortality: Insight from Kailuan study

BACKGROUND: There is limited evidence on the association between arterial stenosis and the risk of all‐cause mortality in cancer patients (ACMC). This study investigated whether the status of arterial function and structure measured by brachial–ankle pulse wave velocity (baPWV) is associated with AC...

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Autores principales: Li, Jiatian, Hidru, Tesfaldet Habtemariam, Lin, Yajuan, Wang, Xinying, Lin, Li, Chen, Shuohua, Xia, Yunlong, Yang, Xiaolei, Wu, Shouling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469642/
https://www.ncbi.nlm.nih.gov/pubmed/37350577
http://dx.doi.org/10.1002/cam4.6251
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author Li, Jiatian
Hidru, Tesfaldet Habtemariam
Lin, Yajuan
Wang, Xinying
Lin, Li
Chen, Shuohua
Xia, Yunlong
Yang, Xiaolei
Wu, Shouling
author_facet Li, Jiatian
Hidru, Tesfaldet Habtemariam
Lin, Yajuan
Wang, Xinying
Lin, Li
Chen, Shuohua
Xia, Yunlong
Yang, Xiaolei
Wu, Shouling
author_sort Li, Jiatian
collection PubMed
description BACKGROUND: There is limited evidence on the association between arterial stenosis and the risk of all‐cause mortality in cancer patients (ACMC). This study investigated whether the status of arterial function and structure measured by brachial–ankle pulse wave velocity (baPWV) is associated with ACMC. METHODS: A total of 43,943 Chinese adults underwent a baPWV examination. Cox proportional hazards model was used to assess the association between the baPWV values and ACMC. RESULTS: During a total follow‐up duration of 3.81 ± 2.50 years, there were 157 deaths among 553 cancer cases diagnosed during the follow‐up. Patients with baPWV ≥18 m/s showed an increased risk of ACMC compared to patients with ideal vascular function. In the multivariate‐adjusted model, we observed a significant association between arterial stiffness severity and ACMC with a hazard ratio (HR) 2.72 (95% confidence interval [CI]: 1.55–4.80; p < 0.001) in those with baPWV ≥18 m/s. With a 1‐SD increase in baPWV, the HR (95% CI) for ACMC in the entire cohort, men, and patients ≤60 years old were 1.20 (95% CI: 1.03–1.41; p < 0.05), 1.20 (95% CI: 1.01–1.43; p < 0.05), and 1.44 (95% CI: 1.10–1.44; p = 0.008), respectively. CONCLUSIONS: Increased arterial stiffness measured by baPWV is associated with ACMC. The association between high baPWV (≥18 m/s) and risk of all‐cause mortality was prominent in men and those ≤60 years of age.
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spelling pubmed-104696422023-09-01 Arterial stiffness is associated with cancer mortality: Insight from Kailuan study Li, Jiatian Hidru, Tesfaldet Habtemariam Lin, Yajuan Wang, Xinying Lin, Li Chen, Shuohua Xia, Yunlong Yang, Xiaolei Wu, Shouling Cancer Med RESEARCH ARTICLES BACKGROUND: There is limited evidence on the association between arterial stenosis and the risk of all‐cause mortality in cancer patients (ACMC). This study investigated whether the status of arterial function and structure measured by brachial–ankle pulse wave velocity (baPWV) is associated with ACMC. METHODS: A total of 43,943 Chinese adults underwent a baPWV examination. Cox proportional hazards model was used to assess the association between the baPWV values and ACMC. RESULTS: During a total follow‐up duration of 3.81 ± 2.50 years, there were 157 deaths among 553 cancer cases diagnosed during the follow‐up. Patients with baPWV ≥18 m/s showed an increased risk of ACMC compared to patients with ideal vascular function. In the multivariate‐adjusted model, we observed a significant association between arterial stiffness severity and ACMC with a hazard ratio (HR) 2.72 (95% confidence interval [CI]: 1.55–4.80; p < 0.001) in those with baPWV ≥18 m/s. With a 1‐SD increase in baPWV, the HR (95% CI) for ACMC in the entire cohort, men, and patients ≤60 years old were 1.20 (95% CI: 1.03–1.41; p < 0.05), 1.20 (95% CI: 1.01–1.43; p < 0.05), and 1.44 (95% CI: 1.10–1.44; p = 0.008), respectively. CONCLUSIONS: Increased arterial stiffness measured by baPWV is associated with ACMC. The association between high baPWV (≥18 m/s) and risk of all‐cause mortality was prominent in men and those ≤60 years of age. John Wiley and Sons Inc. 2023-06-23 /pmc/articles/PMC10469642/ /pubmed/37350577 http://dx.doi.org/10.1002/cam4.6251 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Li, Jiatian
Hidru, Tesfaldet Habtemariam
Lin, Yajuan
Wang, Xinying
Lin, Li
Chen, Shuohua
Xia, Yunlong
Yang, Xiaolei
Wu, Shouling
Arterial stiffness is associated with cancer mortality: Insight from Kailuan study
title Arterial stiffness is associated with cancer mortality: Insight from Kailuan study
title_full Arterial stiffness is associated with cancer mortality: Insight from Kailuan study
title_fullStr Arterial stiffness is associated with cancer mortality: Insight from Kailuan study
title_full_unstemmed Arterial stiffness is associated with cancer mortality: Insight from Kailuan study
title_short Arterial stiffness is associated with cancer mortality: Insight from Kailuan study
title_sort arterial stiffness is associated with cancer mortality: insight from kailuan study
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469642/
https://www.ncbi.nlm.nih.gov/pubmed/37350577
http://dx.doi.org/10.1002/cam4.6251
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