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Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
Represented by feline panleukopenia virus (FPV) and canine parvovirus (CPV), the species carnivore protoparvovirus 1 has a worldwide distribution through continuous ci13rculation in companion animals such as cats and dogs. Subsequently, both FPV and CPV had engaged in host-to-host transfer to other...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469695/ https://www.ncbi.nlm.nih.gov/pubmed/37662912 http://dx.doi.org/10.3389/fimmu.2023.1237630 |
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author | Zhao, Shan Hu, Huanyuan Lan, Jingchao Yang, Zhisong Peng, Qianling Yan, Liheng Luo, Li Wu, Lin Lang, Yifei Yan, Qigui |
author_facet | Zhao, Shan Hu, Huanyuan Lan, Jingchao Yang, Zhisong Peng, Qianling Yan, Liheng Luo, Li Wu, Lin Lang, Yifei Yan, Qigui |
author_sort | Zhao, Shan |
collection | PubMed |
description | Represented by feline panleukopenia virus (FPV) and canine parvovirus (CPV), the species carnivore protoparvovirus 1 has a worldwide distribution through continuous ci13rculation in companion animals such as cats and dogs. Subsequently, both FPV and CPV had engaged in host-to-host transfer to other wild animal hosts of the order Carnivora. In the present study, we emphasized the significance of cross-species transmission of parvoviruses with the isolation and characterization of an FPV from giant panda displaying severe and fatal symptoms. The isolated virus, designated pFPV-sc, displayed similar morphology as FPV, while phylogenetic analysis indicated that the nucleotide sequence of pFPV-sc clades with Chinese FPV isolates. Despite pFPV-sc is seemingly an outcome of a spillover infection event from domestic cats to giant pandas, our study also provided serological evidence that FPV or other parvoviruses closely related to FPV could be already prevalent in giant pandas in 2011. Initiation of host transfer of pFPV-sc is likely with association to giant panda transferrin receptor (TfR), as TfR of giant panda shares high homology with feline TfR. Strikingly, our data also indicate that pFPV-sc can infect cell lines of other mammal species, including humans. To sum up, observations from this study shall promote future research of cross-host transmission and antiviral intervention of Carnivore protoparvovirus 1, and necessitate surveillance studies in thus far unacknowledged potential reservoirs. |
format | Online Article Text |
id | pubmed-10469695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104696952023-09-01 Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential Zhao, Shan Hu, Huanyuan Lan, Jingchao Yang, Zhisong Peng, Qianling Yan, Liheng Luo, Li Wu, Lin Lang, Yifei Yan, Qigui Front Immunol Immunology Represented by feline panleukopenia virus (FPV) and canine parvovirus (CPV), the species carnivore protoparvovirus 1 has a worldwide distribution through continuous ci13rculation in companion animals such as cats and dogs. Subsequently, both FPV and CPV had engaged in host-to-host transfer to other wild animal hosts of the order Carnivora. In the present study, we emphasized the significance of cross-species transmission of parvoviruses with the isolation and characterization of an FPV from giant panda displaying severe and fatal symptoms. The isolated virus, designated pFPV-sc, displayed similar morphology as FPV, while phylogenetic analysis indicated that the nucleotide sequence of pFPV-sc clades with Chinese FPV isolates. Despite pFPV-sc is seemingly an outcome of a spillover infection event from domestic cats to giant pandas, our study also provided serological evidence that FPV or other parvoviruses closely related to FPV could be already prevalent in giant pandas in 2011. Initiation of host transfer of pFPV-sc is likely with association to giant panda transferrin receptor (TfR), as TfR of giant panda shares high homology with feline TfR. Strikingly, our data also indicate that pFPV-sc can infect cell lines of other mammal species, including humans. To sum up, observations from this study shall promote future research of cross-host transmission and antiviral intervention of Carnivore protoparvovirus 1, and necessitate surveillance studies in thus far unacknowledged potential reservoirs. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10469695/ /pubmed/37662912 http://dx.doi.org/10.3389/fimmu.2023.1237630 Text en Copyright © 2023 Zhao, Hu, Lan, Yang, Peng, Yan, Luo, Wu, Lang and Yan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhao, Shan Hu, Huanyuan Lan, Jingchao Yang, Zhisong Peng, Qianling Yan, Liheng Luo, Li Wu, Lin Lang, Yifei Yan, Qigui Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential |
title | Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential |
title_full | Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential |
title_fullStr | Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential |
title_full_unstemmed | Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential |
title_short | Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential |
title_sort | characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469695/ https://www.ncbi.nlm.nih.gov/pubmed/37662912 http://dx.doi.org/10.3389/fimmu.2023.1237630 |
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