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Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential

Represented by feline panleukopenia virus (FPV) and canine parvovirus (CPV), the species carnivore protoparvovirus 1 has a worldwide distribution through continuous ci13rculation in companion animals such as cats and dogs. Subsequently, both FPV and CPV had engaged in host-to-host transfer to other...

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Autores principales: Zhao, Shan, Hu, Huanyuan, Lan, Jingchao, Yang, Zhisong, Peng, Qianling, Yan, Liheng, Luo, Li, Wu, Lin, Lang, Yifei, Yan, Qigui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469695/
https://www.ncbi.nlm.nih.gov/pubmed/37662912
http://dx.doi.org/10.3389/fimmu.2023.1237630
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author Zhao, Shan
Hu, Huanyuan
Lan, Jingchao
Yang, Zhisong
Peng, Qianling
Yan, Liheng
Luo, Li
Wu, Lin
Lang, Yifei
Yan, Qigui
author_facet Zhao, Shan
Hu, Huanyuan
Lan, Jingchao
Yang, Zhisong
Peng, Qianling
Yan, Liheng
Luo, Li
Wu, Lin
Lang, Yifei
Yan, Qigui
author_sort Zhao, Shan
collection PubMed
description Represented by feline panleukopenia virus (FPV) and canine parvovirus (CPV), the species carnivore protoparvovirus 1 has a worldwide distribution through continuous ci13rculation in companion animals such as cats and dogs. Subsequently, both FPV and CPV had engaged in host-to-host transfer to other wild animal hosts of the order Carnivora. In the present study, we emphasized the significance of cross-species transmission of parvoviruses with the isolation and characterization of an FPV from giant panda displaying severe and fatal symptoms. The isolated virus, designated pFPV-sc, displayed similar morphology as FPV, while phylogenetic analysis indicated that the nucleotide sequence of pFPV-sc clades with Chinese FPV isolates. Despite pFPV-sc is seemingly an outcome of a spillover infection event from domestic cats to giant pandas, our study also provided serological evidence that FPV or other parvoviruses closely related to FPV could be already prevalent in giant pandas in 2011. Initiation of host transfer of pFPV-sc is likely with association to giant panda transferrin receptor (TfR), as TfR of giant panda shares high homology with feline TfR. Strikingly, our data also indicate that pFPV-sc can infect cell lines of other mammal species, including humans. To sum up, observations from this study shall promote future research of cross-host transmission and antiviral intervention of Carnivore protoparvovirus 1, and necessitate surveillance studies in thus far unacknowledged potential reservoirs.
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spelling pubmed-104696952023-09-01 Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential Zhao, Shan Hu, Huanyuan Lan, Jingchao Yang, Zhisong Peng, Qianling Yan, Liheng Luo, Li Wu, Lin Lang, Yifei Yan, Qigui Front Immunol Immunology Represented by feline panleukopenia virus (FPV) and canine parvovirus (CPV), the species carnivore protoparvovirus 1 has a worldwide distribution through continuous ci13rculation in companion animals such as cats and dogs. Subsequently, both FPV and CPV had engaged in host-to-host transfer to other wild animal hosts of the order Carnivora. In the present study, we emphasized the significance of cross-species transmission of parvoviruses with the isolation and characterization of an FPV from giant panda displaying severe and fatal symptoms. The isolated virus, designated pFPV-sc, displayed similar morphology as FPV, while phylogenetic analysis indicated that the nucleotide sequence of pFPV-sc clades with Chinese FPV isolates. Despite pFPV-sc is seemingly an outcome of a spillover infection event from domestic cats to giant pandas, our study also provided serological evidence that FPV or other parvoviruses closely related to FPV could be already prevalent in giant pandas in 2011. Initiation of host transfer of pFPV-sc is likely with association to giant panda transferrin receptor (TfR), as TfR of giant panda shares high homology with feline TfR. Strikingly, our data also indicate that pFPV-sc can infect cell lines of other mammal species, including humans. To sum up, observations from this study shall promote future research of cross-host transmission and antiviral intervention of Carnivore protoparvovirus 1, and necessitate surveillance studies in thus far unacknowledged potential reservoirs. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10469695/ /pubmed/37662912 http://dx.doi.org/10.3389/fimmu.2023.1237630 Text en Copyright © 2023 Zhao, Hu, Lan, Yang, Peng, Yan, Luo, Wu, Lang and Yan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Shan
Hu, Huanyuan
Lan, Jingchao
Yang, Zhisong
Peng, Qianling
Yan, Liheng
Luo, Li
Wu, Lin
Lang, Yifei
Yan, Qigui
Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
title Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
title_full Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
title_fullStr Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
title_full_unstemmed Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
title_short Characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
title_sort characterization of a fatal feline panleukopenia virus derived from giant panda with broad cell tropism and zoonotic potential
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469695/
https://www.ncbi.nlm.nih.gov/pubmed/37662912
http://dx.doi.org/10.3389/fimmu.2023.1237630
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