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Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study

BACKGROUND: To explore a new method to reduce radiation‐induced oral mucositis by scheduling radiotherapy for patients with nasopharyngeal carcinoma (NPC) in the corresponding time window of the cycle of oral mucosal cells. METHODS: Eighty‐two NPC patients were randomly divided into a day group (n =...

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Autores principales: Lv, Jun, Liao, Shibin, Li, Bo, Pan, Linjiang, Wang, Rensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469752/
https://www.ncbi.nlm.nih.gov/pubmed/37537945
http://dx.doi.org/10.1002/cam4.6252
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author Lv, Jun
Liao, Shibin
Li, Bo
Pan, Linjiang
Wang, Rensheng
author_facet Lv, Jun
Liao, Shibin
Li, Bo
Pan, Linjiang
Wang, Rensheng
author_sort Lv, Jun
collection PubMed
description BACKGROUND: To explore a new method to reduce radiation‐induced oral mucositis by scheduling radiotherapy for patients with nasopharyngeal carcinoma (NPC) in the corresponding time window of the cycle of oral mucosal cells. METHODS: Eighty‐two NPC patients were randomly divided into a day group (n = 41) and a night group (n = 41). The radiotherapy was scheduled at noon (11:30–15:30) for the day group, while at night (19:00–23:00) for the night group. Oral mucositis and oral pain were recorded in both groups after each radiotherapy fraction. The short‐term efficacy of primary tumor regression, weight loss, and bone marrow suppression was recorded. RESULTS: The incidence of Grade 2 oral mucositis was 87.8% (36/41) and 63.4% (26/41) in the night group and day group, respectively (p = 0.010). The incidence of Grade 3 oral mucositis was 65.9% (27/41) and 22.0% (9/41) in the night group and day group, respectively (p < 0.001). The mean number of radiotherapy for patients to develop Grade 2 oral mucositis was 15.67 ± 5.05 and 20.92 ± 6.21 in the night group and day group, respectively. The incidence of Grade 2 oral pain was 48.8% (20/41) and 22.0% (9/41) in the night group and day group, respectively (p = 0.011). There were no significant differences in tumor regression, weight loss, and bone marrow suppression between the two groups. CONCLUSION: By scheduling radiotherapy based on the corresponding time window of the cycle of oral mucosal cells, the severity of oral mucositis in NPC patients was reduced.
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spelling pubmed-104697522023-09-01 Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study Lv, Jun Liao, Shibin Li, Bo Pan, Linjiang Wang, Rensheng Cancer Med RESEARCH ARTICLES BACKGROUND: To explore a new method to reduce radiation‐induced oral mucositis by scheduling radiotherapy for patients with nasopharyngeal carcinoma (NPC) in the corresponding time window of the cycle of oral mucosal cells. METHODS: Eighty‐two NPC patients were randomly divided into a day group (n = 41) and a night group (n = 41). The radiotherapy was scheduled at noon (11:30–15:30) for the day group, while at night (19:00–23:00) for the night group. Oral mucositis and oral pain were recorded in both groups after each radiotherapy fraction. The short‐term efficacy of primary tumor regression, weight loss, and bone marrow suppression was recorded. RESULTS: The incidence of Grade 2 oral mucositis was 87.8% (36/41) and 63.4% (26/41) in the night group and day group, respectively (p = 0.010). The incidence of Grade 3 oral mucositis was 65.9% (27/41) and 22.0% (9/41) in the night group and day group, respectively (p < 0.001). The mean number of radiotherapy for patients to develop Grade 2 oral mucositis was 15.67 ± 5.05 and 20.92 ± 6.21 in the night group and day group, respectively. The incidence of Grade 2 oral pain was 48.8% (20/41) and 22.0% (9/41) in the night group and day group, respectively (p = 0.011). There were no significant differences in tumor regression, weight loss, and bone marrow suppression between the two groups. CONCLUSION: By scheduling radiotherapy based on the corresponding time window of the cycle of oral mucosal cells, the severity of oral mucositis in NPC patients was reduced. John Wiley and Sons Inc. 2023-08-03 /pmc/articles/PMC10469752/ /pubmed/37537945 http://dx.doi.org/10.1002/cam4.6252 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Lv, Jun
Liao, Shibin
Li, Bo
Pan, Linjiang
Wang, Rensheng
Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study
title Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study
title_full Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study
title_fullStr Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study
title_full_unstemmed Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study
title_short Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study
title_sort scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: a randomized, prospective study
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469752/
https://www.ncbi.nlm.nih.gov/pubmed/37537945
http://dx.doi.org/10.1002/cam4.6252
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