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Insulin signaling and its application
The discovery of insulin in 1921 introduced a new branch of research into insulin activity and insulin resistance. Many discoveries in this field have been applied to diagnosing and treating diseases related to insulin resistance. In this mini-review, the authors attempt to synthesize the updated di...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469844/ https://www.ncbi.nlm.nih.gov/pubmed/37664840 http://dx.doi.org/10.3389/fendo.2023.1226655 |
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author | Le, Thi Kim Chung Dao, Xuan Dat Nguyen, Dang Vung Luu, Duc Huy Bui, Thi Minh Hanh Le, Thi Huong Nguyen, Huu Thang Le, Tran Ngoan Hosaka, Toshio Nguyen, Thi Thu Thao |
author_facet | Le, Thi Kim Chung Dao, Xuan Dat Nguyen, Dang Vung Luu, Duc Huy Bui, Thi Minh Hanh Le, Thi Huong Nguyen, Huu Thang Le, Tran Ngoan Hosaka, Toshio Nguyen, Thi Thu Thao |
author_sort | Le, Thi Kim Chung |
collection | PubMed |
description | The discovery of insulin in 1921 introduced a new branch of research into insulin activity and insulin resistance. Many discoveries in this field have been applied to diagnosing and treating diseases related to insulin resistance. In this mini-review, the authors attempt to synthesize the updated discoveries to unravel the related mechanisms and inform the development of novel applications. Firstly, we depict the insulin signaling pathway to explain the physiology of insulin action starting at the receptor sites of insulin and downstream the signaling of the insulin signaling pathway. Based on this, the next part will analyze the mechanisms of insulin resistance with two major provenances: the defects caused by receptors and the defects due to extra-receptor causes, but in this study, we focus on post-receptor causes. Finally, we discuss the recent applications including the diseases related to insulin resistance (obesity, cardiovascular disease, Alzheimer’s disease, and cancer) and the potential treatment of those based on insulin resistance mechanisms. |
format | Online Article Text |
id | pubmed-10469844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104698442023-09-01 Insulin signaling and its application Le, Thi Kim Chung Dao, Xuan Dat Nguyen, Dang Vung Luu, Duc Huy Bui, Thi Minh Hanh Le, Thi Huong Nguyen, Huu Thang Le, Tran Ngoan Hosaka, Toshio Nguyen, Thi Thu Thao Front Endocrinol (Lausanne) Endocrinology The discovery of insulin in 1921 introduced a new branch of research into insulin activity and insulin resistance. Many discoveries in this field have been applied to diagnosing and treating diseases related to insulin resistance. In this mini-review, the authors attempt to synthesize the updated discoveries to unravel the related mechanisms and inform the development of novel applications. Firstly, we depict the insulin signaling pathway to explain the physiology of insulin action starting at the receptor sites of insulin and downstream the signaling of the insulin signaling pathway. Based on this, the next part will analyze the mechanisms of insulin resistance with two major provenances: the defects caused by receptors and the defects due to extra-receptor causes, but in this study, we focus on post-receptor causes. Finally, we discuss the recent applications including the diseases related to insulin resistance (obesity, cardiovascular disease, Alzheimer’s disease, and cancer) and the potential treatment of those based on insulin resistance mechanisms. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10469844/ /pubmed/37664840 http://dx.doi.org/10.3389/fendo.2023.1226655 Text en Copyright © 2023 Le, Dao, Nguyen, Luu, Bui, Le, Nguyen, Le, Hosaka and Nguyen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Le, Thi Kim Chung Dao, Xuan Dat Nguyen, Dang Vung Luu, Duc Huy Bui, Thi Minh Hanh Le, Thi Huong Nguyen, Huu Thang Le, Tran Ngoan Hosaka, Toshio Nguyen, Thi Thu Thao Insulin signaling and its application |
title | Insulin signaling and its application |
title_full | Insulin signaling and its application |
title_fullStr | Insulin signaling and its application |
title_full_unstemmed | Insulin signaling and its application |
title_short | Insulin signaling and its application |
title_sort | insulin signaling and its application |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469844/ https://www.ncbi.nlm.nih.gov/pubmed/37664840 http://dx.doi.org/10.3389/fendo.2023.1226655 |
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