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Therapeutic potential of TNFR2 agonists: a mechanistic perspective

TNFR2 agonists have been investigated as potential therapies for inflammatory diseases due to their ability to activate and expand immunosuppressive CD4+Foxp3+ Treg cells and myeloid-derived suppressor cells (MDSCs). Despite TNFR2 being predominantly expressed in Treg cells at high levels, activated...

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Detalles Bibliográficos
Autores principales: Chen, Yibo, Jiang, Mengmeng, Chen, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469862/
https://www.ncbi.nlm.nih.gov/pubmed/37662935
http://dx.doi.org/10.3389/fimmu.2023.1209188
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author Chen, Yibo
Jiang, Mengmeng
Chen, Xin
author_facet Chen, Yibo
Jiang, Mengmeng
Chen, Xin
author_sort Chen, Yibo
collection PubMed
description TNFR2 agonists have been investigated as potential therapies for inflammatory diseases due to their ability to activate and expand immunosuppressive CD4+Foxp3+ Treg cells and myeloid-derived suppressor cells (MDSCs). Despite TNFR2 being predominantly expressed in Treg cells at high levels, activated effector T cells also exhibit a certain degree of TNFR2 expression. Consequently, the role of TNFR2 signaling in coordinating immune or inflammatory responses under different pathological conditions is complex. In this review article, we analyze possible factors that may determine the therapeutic outcomes of TNFR2 agonism, including the levels of TNFR2 expression on different cell types, the biological properties of TNFR2 agonists, and disease status. Based on recent progress in the understanding of TNFR2 biology and the study of TNFR2 agonistic agents, we discuss the future direction of developing TNFR2 agonists as a therapeutic agents.
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spelling pubmed-104698622023-09-01 Therapeutic potential of TNFR2 agonists: a mechanistic perspective Chen, Yibo Jiang, Mengmeng Chen, Xin Front Immunol Immunology TNFR2 agonists have been investigated as potential therapies for inflammatory diseases due to their ability to activate and expand immunosuppressive CD4+Foxp3+ Treg cells and myeloid-derived suppressor cells (MDSCs). Despite TNFR2 being predominantly expressed in Treg cells at high levels, activated effector T cells also exhibit a certain degree of TNFR2 expression. Consequently, the role of TNFR2 signaling in coordinating immune or inflammatory responses under different pathological conditions is complex. In this review article, we analyze possible factors that may determine the therapeutic outcomes of TNFR2 agonism, including the levels of TNFR2 expression on different cell types, the biological properties of TNFR2 agonists, and disease status. Based on recent progress in the understanding of TNFR2 biology and the study of TNFR2 agonistic agents, we discuss the future direction of developing TNFR2 agonists as a therapeutic agents. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10469862/ /pubmed/37662935 http://dx.doi.org/10.3389/fimmu.2023.1209188 Text en Copyright © 2023 Chen, Jiang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Yibo
Jiang, Mengmeng
Chen, Xin
Therapeutic potential of TNFR2 agonists: a mechanistic perspective
title Therapeutic potential of TNFR2 agonists: a mechanistic perspective
title_full Therapeutic potential of TNFR2 agonists: a mechanistic perspective
title_fullStr Therapeutic potential of TNFR2 agonists: a mechanistic perspective
title_full_unstemmed Therapeutic potential of TNFR2 agonists: a mechanistic perspective
title_short Therapeutic potential of TNFR2 agonists: a mechanistic perspective
title_sort therapeutic potential of tnfr2 agonists: a mechanistic perspective
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469862/
https://www.ncbi.nlm.nih.gov/pubmed/37662935
http://dx.doi.org/10.3389/fimmu.2023.1209188
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