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Zebrafish as an emerging model to study estrogen receptors in neural development

Estrogens induce several regulatory signals in the nervous system that are mainly mediated through estrogen receptors (ERs). ERs are largely expressed in the nervous system, yet the importance of ERs to neural development has only been elucidated over the last decades. Accumulating evidence shows a...

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Autores principales: Boueid, Marie-José, El-Hage, Océane, Schumacher, Michael, Degerny, Cindy, Tawk, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469878/
https://www.ncbi.nlm.nih.gov/pubmed/37664862
http://dx.doi.org/10.3389/fendo.2023.1240018
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author Boueid, Marie-José
El-Hage, Océane
Schumacher, Michael
Degerny, Cindy
Tawk, Marcel
author_facet Boueid, Marie-José
El-Hage, Océane
Schumacher, Michael
Degerny, Cindy
Tawk, Marcel
author_sort Boueid, Marie-José
collection PubMed
description Estrogens induce several regulatory signals in the nervous system that are mainly mediated through estrogen receptors (ERs). ERs are largely expressed in the nervous system, yet the importance of ERs to neural development has only been elucidated over the last decades. Accumulating evidence shows a fundamental role for estrogens in the development of the central and peripheral nervous systems, hence, the contribution of ERs to neural function is now a growing area of research. The conservation of the structure of the ERs and their response to estrogens make the zebrafish an interesting model to dissect the role of estrogens in the nervous system. In this review, we highlight major findings of ER signaling in embryonic zebrafish neural development and compare the similarities and differences to research in rodents. We also discuss how the recent generation of zebrafish ER mutants, coupled with the availability of several transgenic reporter lines, its amenability to pharmacological studies and in vivo live imaging, could help us explore ER function in embryonic neural development.
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spelling pubmed-104698782023-09-01 Zebrafish as an emerging model to study estrogen receptors in neural development Boueid, Marie-José El-Hage, Océane Schumacher, Michael Degerny, Cindy Tawk, Marcel Front Endocrinol (Lausanne) Endocrinology Estrogens induce several regulatory signals in the nervous system that are mainly mediated through estrogen receptors (ERs). ERs are largely expressed in the nervous system, yet the importance of ERs to neural development has only been elucidated over the last decades. Accumulating evidence shows a fundamental role for estrogens in the development of the central and peripheral nervous systems, hence, the contribution of ERs to neural function is now a growing area of research. The conservation of the structure of the ERs and their response to estrogens make the zebrafish an interesting model to dissect the role of estrogens in the nervous system. In this review, we highlight major findings of ER signaling in embryonic zebrafish neural development and compare the similarities and differences to research in rodents. We also discuss how the recent generation of zebrafish ER mutants, coupled with the availability of several transgenic reporter lines, its amenability to pharmacological studies and in vivo live imaging, could help us explore ER function in embryonic neural development. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10469878/ /pubmed/37664862 http://dx.doi.org/10.3389/fendo.2023.1240018 Text en Copyright © 2023 Boueid, El-Hage, Schumacher, Degerny and Tawk https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Boueid, Marie-José
El-Hage, Océane
Schumacher, Michael
Degerny, Cindy
Tawk, Marcel
Zebrafish as an emerging model to study estrogen receptors in neural development
title Zebrafish as an emerging model to study estrogen receptors in neural development
title_full Zebrafish as an emerging model to study estrogen receptors in neural development
title_fullStr Zebrafish as an emerging model to study estrogen receptors in neural development
title_full_unstemmed Zebrafish as an emerging model to study estrogen receptors in neural development
title_short Zebrafish as an emerging model to study estrogen receptors in neural development
title_sort zebrafish as an emerging model to study estrogen receptors in neural development
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469878/
https://www.ncbi.nlm.nih.gov/pubmed/37664862
http://dx.doi.org/10.3389/fendo.2023.1240018
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