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A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma
The current TNM staging system for pancreatic ductal adenocarcinoma (PDAC) has revised the definitions of T and N categories as well as stage groups. However, studies validating these modifications have yielded inconsistent results. The existing TNM staging system in prognostic prediction remains un...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469961/ https://www.ncbi.nlm.nih.gov/pubmed/37664604 http://dx.doi.org/10.1016/j.isci.2023.107589 |
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author | Liang, Yuexiang Cui, Jingli Ding, Fanghui Zou, Yiping Guo, Hanhan Man, Quan Chang, Shaofei Gao, Song Hao, Jihui |
author_facet | Liang, Yuexiang Cui, Jingli Ding, Fanghui Zou, Yiping Guo, Hanhan Man, Quan Chang, Shaofei Gao, Song Hao, Jihui |
author_sort | Liang, Yuexiang |
collection | PubMed |
description | The current TNM staging system for pancreatic ductal adenocarcinoma (PDAC) has revised the definitions of T and N categories as well as stage groups. However, studies validating these modifications have yielded inconsistent results. The existing TNM staging system in prognostic prediction remains unsatisfactory. The prognosis of PDAC is closely associated with pathological and biological factors. Herein, we propose a new staging system incorporating distant metastasis, postoperative serum levels of CA19-9 and CEA, tumor size, lymph node metastasis, lymphovascular involvement, and perineural invasion to enhance the accuracy of prognosis assessment. The proposed staging system exhibited a strong correlation with both overall survival and recurrence-free survival, effectively stratifying survival into five distinct tiers. Additionally, it had favorable discrimination and calibration. Thus, the proposed staging system demonstrates superior prognostic performance compared to the TNM staging system, and can serve as a valuable complementary tool to address the limitations of TNM staging in prognostication. |
format | Online Article Text |
id | pubmed-10469961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104699612023-09-01 A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma Liang, Yuexiang Cui, Jingli Ding, Fanghui Zou, Yiping Guo, Hanhan Man, Quan Chang, Shaofei Gao, Song Hao, Jihui iScience Article The current TNM staging system for pancreatic ductal adenocarcinoma (PDAC) has revised the definitions of T and N categories as well as stage groups. However, studies validating these modifications have yielded inconsistent results. The existing TNM staging system in prognostic prediction remains unsatisfactory. The prognosis of PDAC is closely associated with pathological and biological factors. Herein, we propose a new staging system incorporating distant metastasis, postoperative serum levels of CA19-9 and CEA, tumor size, lymph node metastasis, lymphovascular involvement, and perineural invasion to enhance the accuracy of prognosis assessment. The proposed staging system exhibited a strong correlation with both overall survival and recurrence-free survival, effectively stratifying survival into five distinct tiers. Additionally, it had favorable discrimination and calibration. Thus, the proposed staging system demonstrates superior prognostic performance compared to the TNM staging system, and can serve as a valuable complementary tool to address the limitations of TNM staging in prognostication. Elsevier 2023-08-09 /pmc/articles/PMC10469961/ /pubmed/37664604 http://dx.doi.org/10.1016/j.isci.2023.107589 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Liang, Yuexiang Cui, Jingli Ding, Fanghui Zou, Yiping Guo, Hanhan Man, Quan Chang, Shaofei Gao, Song Hao, Jihui A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma |
title | A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma |
title_full | A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma |
title_fullStr | A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma |
title_full_unstemmed | A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma |
title_short | A new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma |
title_sort | new staging system for postoperative prognostication in pancreatic ductal adenocarcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469961/ https://www.ncbi.nlm.nih.gov/pubmed/37664604 http://dx.doi.org/10.1016/j.isci.2023.107589 |
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