SUZ domain–containing proteins have multiple effects on nonsense-mediated decay target transcripts

Many transcripts are targeted by nonsense-mediated decay (NMD), leading to their degradation and the inhibition of their translation. We found that the protein SUZ domain–containing protein 1 (SZRD1) interacts with the key NMD factor up-frameshift 1. When recruited to NMD-sensitive reporter gene tra...

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Detalles Bibliográficos
Autores principales: Halbout, Mathias, Bury, Marina, Hanet, Aoife, Gerin, Isabelle, Graff, Julie, Killian, Theodore, Gatto, Laurent, Vertommen, Didier, Bommer, Guido T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470013/
https://www.ncbi.nlm.nih.gov/pubmed/37507022
http://dx.doi.org/10.1016/j.jbc.2023.105095

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