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Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases
Recent discoveries establish tRNAs as central regulators of mRNA translation dynamics, and therefore cotranslational folding and function of the encoded protein. The tRNA pool, whose composition and abundance change in a cell- and tissue-dependent manner, is the main factor which determines mRNA tra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470029/ https://www.ncbi.nlm.nih.gov/pubmed/37495112 http://dx.doi.org/10.1016/j.jbc.2023.105089 |
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author | Davyt, Marcos Bharti, Nikhil Ignatova, Zoya |
author_facet | Davyt, Marcos Bharti, Nikhil Ignatova, Zoya |
author_sort | Davyt, Marcos |
collection | PubMed |
description | Recent discoveries establish tRNAs as central regulators of mRNA translation dynamics, and therefore cotranslational folding and function of the encoded protein. The tRNA pool, whose composition and abundance change in a cell- and tissue-dependent manner, is the main factor which determines mRNA translation velocity. In this review, we discuss a group of pathogenic mutations, in the coding sequences of either protein-coding genes or in tRNA genes, that alter mRNA translation dynamics. We also summarize advances in tRNA biology that have uncovered how variations in tRNA levels on account of genetic mutations affect protein folding and function, and thereby contribute to phenotypic diversity in clinical manifestations. |
format | Online Article Text |
id | pubmed-10470029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-104700292023-09-01 Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases Davyt, Marcos Bharti, Nikhil Ignatova, Zoya J Biol Chem JBC Reviews Recent discoveries establish tRNAs as central regulators of mRNA translation dynamics, and therefore cotranslational folding and function of the encoded protein. The tRNA pool, whose composition and abundance change in a cell- and tissue-dependent manner, is the main factor which determines mRNA translation velocity. In this review, we discuss a group of pathogenic mutations, in the coding sequences of either protein-coding genes or in tRNA genes, that alter mRNA translation dynamics. We also summarize advances in tRNA biology that have uncovered how variations in tRNA levels on account of genetic mutations affect protein folding and function, and thereby contribute to phenotypic diversity in clinical manifestations. American Society for Biochemistry and Molecular Biology 2023-07-24 /pmc/articles/PMC10470029/ /pubmed/37495112 http://dx.doi.org/10.1016/j.jbc.2023.105089 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | JBC Reviews Davyt, Marcos Bharti, Nikhil Ignatova, Zoya Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases |
title | Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases |
title_full | Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases |
title_fullStr | Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases |
title_full_unstemmed | Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases |
title_short | Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases |
title_sort | effect of mrna/trna mutations on translation speed: implications for human diseases |
topic | JBC Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470029/ https://www.ncbi.nlm.nih.gov/pubmed/37495112 http://dx.doi.org/10.1016/j.jbc.2023.105089 |
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