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Elucidating the roles of the mammary and gut microbiomes in breast cancer development
The mammary microbiome is a newly characterized bacterial niche that might offer biological insight into the development of breast cancer. Together with in-depth analysis of the gut microbiome in breast cancer, current evidence using next-generation sequencing and metabolic profiling suggests compos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470065/ https://www.ncbi.nlm.nih.gov/pubmed/37664075 http://dx.doi.org/10.3389/fonc.2023.1198259 |
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author | Hoskinson, Courtney Jiang, Rachel Yutong Stiemsma, Leah T. |
author_facet | Hoskinson, Courtney Jiang, Rachel Yutong Stiemsma, Leah T. |
author_sort | Hoskinson, Courtney |
collection | PubMed |
description | The mammary microbiome is a newly characterized bacterial niche that might offer biological insight into the development of breast cancer. Together with in-depth analysis of the gut microbiome in breast cancer, current evidence using next-generation sequencing and metabolic profiling suggests compositional and functional shifts in microbial consortia are associated with breast cancer. In this review, we discuss the fundamental studies that have progressed this important area of research, focusing on the roles of both the mammary tissue microbiome and the gut microbiome. From the literature, we identified the following major conclusions, (I) There are unique breast and gut microbial signatures (both compositional and functional) that are associated with breast cancer, (II) breast and gut microbiome compositional and breast functional dysbiosis represent potential early events of breast tumor development, (III) specific breast and gut microbes confer host immune responses that can combat breast tumor development and progression, and (IV) chemotherapies alter the microbiome and thus maintenance of a eubiotic microbiome may be key in breast cancer treatment. As the field expectantly advances, it is necessary for the role of the microbiome to continue to be elucidated using multi-omic approaches and translational animal models in order to improve predictive, preventive, and therapeutic strategies for breast cancer. |
format | Online Article Text |
id | pubmed-10470065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104700652023-09-01 Elucidating the roles of the mammary and gut microbiomes in breast cancer development Hoskinson, Courtney Jiang, Rachel Yutong Stiemsma, Leah T. Front Oncol Oncology The mammary microbiome is a newly characterized bacterial niche that might offer biological insight into the development of breast cancer. Together with in-depth analysis of the gut microbiome in breast cancer, current evidence using next-generation sequencing and metabolic profiling suggests compositional and functional shifts in microbial consortia are associated with breast cancer. In this review, we discuss the fundamental studies that have progressed this important area of research, focusing on the roles of both the mammary tissue microbiome and the gut microbiome. From the literature, we identified the following major conclusions, (I) There are unique breast and gut microbial signatures (both compositional and functional) that are associated with breast cancer, (II) breast and gut microbiome compositional and breast functional dysbiosis represent potential early events of breast tumor development, (III) specific breast and gut microbes confer host immune responses that can combat breast tumor development and progression, and (IV) chemotherapies alter the microbiome and thus maintenance of a eubiotic microbiome may be key in breast cancer treatment. As the field expectantly advances, it is necessary for the role of the microbiome to continue to be elucidated using multi-omic approaches and translational animal models in order to improve predictive, preventive, and therapeutic strategies for breast cancer. Frontiers Media S.A. 2023-08-17 /pmc/articles/PMC10470065/ /pubmed/37664075 http://dx.doi.org/10.3389/fonc.2023.1198259 Text en Copyright © 2023 Hoskinson, Jiang and Stiemsma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Hoskinson, Courtney Jiang, Rachel Yutong Stiemsma, Leah T. Elucidating the roles of the mammary and gut microbiomes in breast cancer development |
title | Elucidating the roles of the mammary and gut microbiomes in breast cancer development |
title_full | Elucidating the roles of the mammary and gut microbiomes in breast cancer development |
title_fullStr | Elucidating the roles of the mammary and gut microbiomes in breast cancer development |
title_full_unstemmed | Elucidating the roles of the mammary and gut microbiomes in breast cancer development |
title_short | Elucidating the roles of the mammary and gut microbiomes in breast cancer development |
title_sort | elucidating the roles of the mammary and gut microbiomes in breast cancer development |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470065/ https://www.ncbi.nlm.nih.gov/pubmed/37664075 http://dx.doi.org/10.3389/fonc.2023.1198259 |
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