Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy

Mutations in the DNA helicase RECQL4 lead to Rothmund–Thomson syndrome (RTS), a disorder characterized by mitochondrial dysfunctions, premature aging, and genomic instability. However, the mechanisms by which these mutations lead to pathology are unclear. Here we report that RECQL4 is ubiquitylated...

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Detalles Bibliográficos
Autores principales: Hussain, Mansoor, Mohammed, Aftab, Saifi, Shabnam, Priya, Swati, Sengupta, Sagar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470078/
https://www.ncbi.nlm.nih.gov/pubmed/37495109
http://dx.doi.org/10.1016/j.jbc.2023.105087

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