Intranasal inoculation of female BALB/c mice with replication-deficient human adenovirus type 5 expressing SARS-CoV‐2 nucleocapsid protein aggravates lung pathology upon re-encountering the antigen

Preclinical studies indicate that SARS-CoV-2 nucleocapsid (N)-based vaccines, along with other viral protein(s), confer protection in various animal models against infection by SARS-CoV-2 ancestral virus and variants of concern. However, the optimal vaccination procedure and the role of N-specific h...

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Detalles Bibliográficos
Autores principales: Cao, Junxia, Gu, Hongjing, Zhang, Xueting, Yun, Hongfang, Li, Jiarong, Si, Chuan-Yimu, Zhang, Jiyan, Wang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470087/
https://www.ncbi.nlm.nih.gov/pubmed/37595663
http://dx.doi.org/10.1016/j.virusres.2023.199201

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