Antidepressants and type 2 diabetes: highways to knowns and unknowns

Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in T2D patients. Therefore, management of depression by antidep...

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Autores principales: Alruwaili, Nahi Sabih, Al-Kuraishy, Hayder M., Al-Gareeb, Ali I., Albuhadily, Ali K., Ragab, Amany E., Alenazi, Ahmad Awad, Alexiou, Athanasios, Papadakis, Marios, Batiha, Gaber El-Saber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470155/
https://www.ncbi.nlm.nih.gov/pubmed/37653558
http://dx.doi.org/10.1186/s13098-023-01149-z
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author Alruwaili, Nahi Sabih
Al-Kuraishy, Hayder M.
Al-Gareeb, Ali I.
Albuhadily, Ali K.
Ragab, Amany E.
Alenazi, Ahmad Awad
Alexiou, Athanasios
Papadakis, Marios
Batiha, Gaber El-Saber
author_facet Alruwaili, Nahi Sabih
Al-Kuraishy, Hayder M.
Al-Gareeb, Ali I.
Albuhadily, Ali K.
Ragab, Amany E.
Alenazi, Ahmad Awad
Alexiou, Athanasios
Papadakis, Marios
Batiha, Gaber El-Saber
author_sort Alruwaili, Nahi Sabih
collection PubMed
description Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in T2D patients. Therefore, management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity. However, prolong use of antidepressant drugs may increase the risk for the development of T2D. However, there is strong controversy concerning the use of antidepressant drugs in T2D. Therefore, this review try to elucidate the potential effects of antidepressant drugs in T2D regarding their detrimental and beneficial effects.
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spelling pubmed-104701552023-09-01 Antidepressants and type 2 diabetes: highways to knowns and unknowns Alruwaili, Nahi Sabih Al-Kuraishy, Hayder M. Al-Gareeb, Ali I. Albuhadily, Ali K. Ragab, Amany E. Alenazi, Ahmad Awad Alexiou, Athanasios Papadakis, Marios Batiha, Gaber El-Saber Diabetol Metab Syndr Review Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in T2D patients. Therefore, management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity. However, prolong use of antidepressant drugs may increase the risk for the development of T2D. However, there is strong controversy concerning the use of antidepressant drugs in T2D. Therefore, this review try to elucidate the potential effects of antidepressant drugs in T2D regarding their detrimental and beneficial effects. BioMed Central 2023-08-31 /pmc/articles/PMC10470155/ /pubmed/37653558 http://dx.doi.org/10.1186/s13098-023-01149-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Alruwaili, Nahi Sabih
Al-Kuraishy, Hayder M.
Al-Gareeb, Ali I.
Albuhadily, Ali K.
Ragab, Amany E.
Alenazi, Ahmad Awad
Alexiou, Athanasios
Papadakis, Marios
Batiha, Gaber El-Saber
Antidepressants and type 2 diabetes: highways to knowns and unknowns
title Antidepressants and type 2 diabetes: highways to knowns and unknowns
title_full Antidepressants and type 2 diabetes: highways to knowns and unknowns
title_fullStr Antidepressants and type 2 diabetes: highways to knowns and unknowns
title_full_unstemmed Antidepressants and type 2 diabetes: highways to knowns and unknowns
title_short Antidepressants and type 2 diabetes: highways to knowns and unknowns
title_sort antidepressants and type 2 diabetes: highways to knowns and unknowns
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470155/
https://www.ncbi.nlm.nih.gov/pubmed/37653558
http://dx.doi.org/10.1186/s13098-023-01149-z
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