Cargando…
Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis
BACKGROUND: Interleukin (IL)-36 family cytokines have received increasing attention, especially in the fields of inflammation and immunity research. However, whether IL-36 family cytokine levels are correlated with the results of the assessment of allergic rhinitis (AR) and affect the severity of AR...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470177/ https://www.ncbi.nlm.nih.gov/pubmed/37649097 http://dx.doi.org/10.1186/s13223-023-00834-y |
_version_ | 1785099627778801664 |
---|---|
author | Gu, Jia Qin, Gang Jiang, Liang Xu, Wei Wang, Yuanyuan Liao, Jiangxue Pan, Hongzhu Liang, Zhuoping |
author_facet | Gu, Jia Qin, Gang Jiang, Liang Xu, Wei Wang, Yuanyuan Liao, Jiangxue Pan, Hongzhu Liang, Zhuoping |
author_sort | Gu, Jia |
collection | PubMed |
description | BACKGROUND: Interleukin (IL)-36 family cytokines have received increasing attention, especially in the fields of inflammation and immunity research. However, whether IL-36 family cytokine levels are correlated with the results of the assessment of allergic rhinitis (AR) and affect the severity of AR remains unknown. Therefore, this study aimed to investigate the correlations between IL-36 family cytokine levels and subjective and objective assessment results and to further analyze the possible mechanisms of IL-36 family cytokines in the development of AR. METHODS: An enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of the IL-36 family cytokines IL-36α, IL-36β, IL-36γ, IL-36Ra, and IL-38 in the peripheral blood of patients with AR. The condition of patients with AR was assessed by 22-item sino-nasal outcome test (SNOT-22) score, visual analogue scale (VAS) scores for disease severity, and serum inhalant allergen immunoglobulin E (IgE) detection. Correlations between IL-36 family cytokine levels and subjective and objective assessment results in patients with AR were analyzed. RESULTS: The concentration of IL-36α in the peripheral blood of patients with AR was the highest, and the concentration of IL-36β was the lowest. The concentration of IL-36α was higher in juvenile patients than in adult patients, and there was a difference in the IL-36Ra level between the perennial allergen group and the seasonal allergen group. There was a positive correlation between IL-36α level and IL-36γ level, IL-36γ level and IL-36Ra level, and IL-36Ra level and IL-38 level, and IL-36β level was positively correlated with IL-36Ra and IL-38 levels, respectively. IL-36α level was positively correlated with VAS score for nasal congestion symptom. IL-36β level was positively correlated with the total VAS score for ocular symptoms and VAS scores for ocular itching and eye pain symptoms. However, there was no correlation between the levels of all cytokines in IL-36 family and SNOT-22 score, the number of positive inhaled allergens, or the highest positive intensity of allergen specific immunoglobulin E (sIgE). CONCLUSION: Peripheral blood IL-36 family cytokines play an important role in AR, and the concentrations of IL-36α and IL-36β were related to the severity of symptoms in patients with AR. |
format | Online Article Text |
id | pubmed-10470177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104701772023-09-01 Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis Gu, Jia Qin, Gang Jiang, Liang Xu, Wei Wang, Yuanyuan Liao, Jiangxue Pan, Hongzhu Liang, Zhuoping Allergy Asthma Clin Immunol Research BACKGROUND: Interleukin (IL)-36 family cytokines have received increasing attention, especially in the fields of inflammation and immunity research. However, whether IL-36 family cytokine levels are correlated with the results of the assessment of allergic rhinitis (AR) and affect the severity of AR remains unknown. Therefore, this study aimed to investigate the correlations between IL-36 family cytokine levels and subjective and objective assessment results and to further analyze the possible mechanisms of IL-36 family cytokines in the development of AR. METHODS: An enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of the IL-36 family cytokines IL-36α, IL-36β, IL-36γ, IL-36Ra, and IL-38 in the peripheral blood of patients with AR. The condition of patients with AR was assessed by 22-item sino-nasal outcome test (SNOT-22) score, visual analogue scale (VAS) scores for disease severity, and serum inhalant allergen immunoglobulin E (IgE) detection. Correlations between IL-36 family cytokine levels and subjective and objective assessment results in patients with AR were analyzed. RESULTS: The concentration of IL-36α in the peripheral blood of patients with AR was the highest, and the concentration of IL-36β was the lowest. The concentration of IL-36α was higher in juvenile patients than in adult patients, and there was a difference in the IL-36Ra level between the perennial allergen group and the seasonal allergen group. There was a positive correlation between IL-36α level and IL-36γ level, IL-36γ level and IL-36Ra level, and IL-36Ra level and IL-38 level, and IL-36β level was positively correlated with IL-36Ra and IL-38 levels, respectively. IL-36α level was positively correlated with VAS score for nasal congestion symptom. IL-36β level was positively correlated with the total VAS score for ocular symptoms and VAS scores for ocular itching and eye pain symptoms. However, there was no correlation between the levels of all cytokines in IL-36 family and SNOT-22 score, the number of positive inhaled allergens, or the highest positive intensity of allergen specific immunoglobulin E (sIgE). CONCLUSION: Peripheral blood IL-36 family cytokines play an important role in AR, and the concentrations of IL-36α and IL-36β were related to the severity of symptoms in patients with AR. BioMed Central 2023-08-30 /pmc/articles/PMC10470177/ /pubmed/37649097 http://dx.doi.org/10.1186/s13223-023-00834-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Gu, Jia Qin, Gang Jiang, Liang Xu, Wei Wang, Yuanyuan Liao, Jiangxue Pan, Hongzhu Liang, Zhuoping Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis |
title | Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis |
title_full | Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis |
title_fullStr | Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis |
title_full_unstemmed | Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis |
title_short | Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis |
title_sort | correlations between il-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470177/ https://www.ncbi.nlm.nih.gov/pubmed/37649097 http://dx.doi.org/10.1186/s13223-023-00834-y |
work_keys_str_mv | AT gujia correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis AT qingang correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis AT jiangliang correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis AT xuwei correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis AT wangyuanyuan correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis AT liaojiangxue correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis AT panhongzhu correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis AT liangzhuoping correlationsbetweenil36familycytokinesinperipheralbloodandsubjectiveandobjectiveassessmentresultsinpatientswithallergicrhinitis |