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Impact of organic chemistry conditions on DNA durability in the context of DNA-encoded library technology

High-power screening (HPS) technologies, such as DNA-encoded library (DEL) technology, could exponentially increase the dimensions of the chemical space accessible for drug discovery. The intrinsic fragile nature of DNA is associated with cumbersome limitations and DNA durability (e.g., depurination...

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Detalles Bibliográficos
Autores principales:	Sunkari, Yashoda Krishna, Nguyen, Thu-Lan, Siripuram, Vijay Kumar, Flajolet, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470182/ https://www.ncbi.nlm.nih.gov/pubmed/37664608 http://dx.doi.org/10.1016/j.isci.2023.107573

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