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Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding
Human cytochrome P450 3A4 (CYP3A4) is a major drug-metabolizing enzyme that shows extreme substrate promiscuity. Moreover, its large and malleable active site can simultaneously accommodate several substrate molecules of the same or different nature, which may lead to cooperative binding and alloste...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470200/ https://www.ncbi.nlm.nih.gov/pubmed/37524132 http://dx.doi.org/10.1016/j.jbc.2023.105117 |