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N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test

BACKGROUND: Heart rate recovery (HRR) and N terminal-pro B type natriuretic peptide (NT-proBNP) are markers for survival and cardiac function; however, Little is known about their association. METHOD: We examined 2540 healthy subjects aged 12–49 years with data from National Health and Nutrition Exa...

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Autores principales: Lin, Yi-Ting, Lin, Lian-Yu, Chuang, Kai-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470307/
https://www.ncbi.nlm.nih.gov/pubmed/37664165
http://dx.doi.org/10.1016/j.ijcrp.2023.200203
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author Lin, Yi-Ting
Lin, Lian-Yu
Chuang, Kai-Jen
author_facet Lin, Yi-Ting
Lin, Lian-Yu
Chuang, Kai-Jen
author_sort Lin, Yi-Ting
collection PubMed
description BACKGROUND: Heart rate recovery (HRR) and N terminal-pro B type natriuretic peptide (NT-proBNP) are markers for survival and cardiac function; however, Little is known about their association. METHOD: We examined 2540 healthy subjects aged 12–49 years with data from National Health and Nutrition Examination Survey(NHANES) 1999–2002. HRR parameters 1–3 min after exercise were calculated from exercise test results. Baseline characteristics, anthropometric and NT-proBNP, and other risk covariates were obtained. RESULT: The results showed that NT-proBNP was positively correlated with HRR2(correlation coefficient (cc) = 0.042 [0.029–0.054], P < 0.001) and HRR3(cc = 0.046 [0.029–0.064], P = 0.001); with further adjustment, the associations remained significant between NT-proBNP and HRR2(cc = 0.030 [0.010–0.049], P = 0.004)/HRR3(cc = 0.029[0.004–0.054], P = 0.025). Our study also found significant correlations between NT-pro BNP and SBP(cc = −0.026 [-0.046∼-0.005], P = 0.017), DBP(cc = −0.037 [-0.062∼-0.012], P = 0.005), and total cholesterol(cc = −0.065 [-0.12∼-0.018], P = 0.009). CONCLUSIONS: Our results suggest that BNP might reduce heart rate after exercise by inhibiting the sympathetic nervous system (SNS), reducing HRR2 and HRR3, as these phases involve the reduction of heart rate through cardiac sympathetic withdrawal. Moreover, the interaction of BNP on the SNS might be related to the effect of BNP on cardiovascular risks.
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spelling pubmed-104703072023-09-01 N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test Lin, Yi-Ting Lin, Lian-Yu Chuang, Kai-Jen Int J Cardiol Cardiovasc Risk Prev Research Paper BACKGROUND: Heart rate recovery (HRR) and N terminal-pro B type natriuretic peptide (NT-proBNP) are markers for survival and cardiac function; however, Little is known about their association. METHOD: We examined 2540 healthy subjects aged 12–49 years with data from National Health and Nutrition Examination Survey(NHANES) 1999–2002. HRR parameters 1–3 min after exercise were calculated from exercise test results. Baseline characteristics, anthropometric and NT-proBNP, and other risk covariates were obtained. RESULT: The results showed that NT-proBNP was positively correlated with HRR2(correlation coefficient (cc) = 0.042 [0.029–0.054], P < 0.001) and HRR3(cc = 0.046 [0.029–0.064], P = 0.001); with further adjustment, the associations remained significant between NT-proBNP and HRR2(cc = 0.030 [0.010–0.049], P = 0.004)/HRR3(cc = 0.029[0.004–0.054], P = 0.025). Our study also found significant correlations between NT-pro BNP and SBP(cc = −0.026 [-0.046∼-0.005], P = 0.017), DBP(cc = −0.037 [-0.062∼-0.012], P = 0.005), and total cholesterol(cc = −0.065 [-0.12∼-0.018], P = 0.009). CONCLUSIONS: Our results suggest that BNP might reduce heart rate after exercise by inhibiting the sympathetic nervous system (SNS), reducing HRR2 and HRR3, as these phases involve the reduction of heart rate through cardiac sympathetic withdrawal. Moreover, the interaction of BNP on the SNS might be related to the effect of BNP on cardiovascular risks. Elsevier 2023-08-17 /pmc/articles/PMC10470307/ /pubmed/37664165 http://dx.doi.org/10.1016/j.ijcrp.2023.200203 Text en © 2023 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Paper
Lin, Yi-Ting
Lin, Lian-Yu
Chuang, Kai-Jen
N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test
title N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test
title_full N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test
title_fullStr N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test
title_full_unstemmed N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test
title_short N terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test
title_sort n terminal prohormone of brain natriuretic peptide is associated with improved heart rate recovery after treadmill exercise test
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470307/
https://www.ncbi.nlm.nih.gov/pubmed/37664165
http://dx.doi.org/10.1016/j.ijcrp.2023.200203
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