Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration

BACKGROUND AND AIMS: Active intestinal stem cells are prone to injury by ionizing radiation. We previously showed that upon radiation-induced injury, normally quiescent reserve intestinal stem cells (rISCs) (marked by BMI1) are activated by Musashi-1 (MSI1) and exit from the quiescent state to regen...

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Detalles Bibliográficos
Autores principales: Orzechowska-Licari, Emilia J., Bialkowska, Agnieszka B., Yang, Vincent W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470419/
https://www.ncbi.nlm.nih.gov/pubmed/37481204
http://dx.doi.org/10.1016/j.jcmgh.2023.07.004

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