LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity

Mitochondrial dysfunction is one of the key features of acute kidney injury (AKI) and associated fibrosis. Leucine-rich repeat kinase 2 (LRRK2) is highly expressed in kidneys and regulates mitochondrial homeostasis. How it functions in AKI is unclear. Herein we reported that LRRK2 was dramatically d...

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Detalles Bibliográficos
Autores principales: Zhang, Shun, Qian, Subo, Liu, Hailong, Xu, Ding, Xia, Weimin, Duan, Huangqi, Wang, Chen, Yu, Shenggen, Chen, Yingying, Ji, Ping, Wang, Shujun, Cui, Xingang, Wang, Ying, Shen, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470420/
https://www.ncbi.nlm.nih.gov/pubmed/37633049
http://dx.doi.org/10.1016/j.redox.2023.102860

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